|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013935,
umls-concept:C0017262,
umls-concept:C0021400,
umls-concept:C0033684,
umls-concept:C0040649,
umls-concept:C0085140,
umls-concept:C0220843,
umls-concept:C0257018,
umls-concept:C0332120,
umls-concept:C1171362,
umls-concept:C1515670
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2001-10-24
|
|
pubmed:abstractText |
The DLX homeodomain proteins control development of the basal ganglia and branchial arches. To identify co-factors that regulate DLX function we utilized the yeast two-hybrid assay, and found a DLX interacting protein (DIP2) which binds to the N-terminal region of DLX2 via a PDZ domain. DIP2 appears to be an alternatively spliced form of GRIP1, a protein known to bind AMPA glutamate receptors via PDZ domains. Thus, we named it GRIP1b. We provide evidence that GRIP1b can function as a transcriptional co-activator of DLX2 and DLX5. Glutamate receptors inhibit this co-activation. These results suggest that some PDZ proteins may regulate transcription via their interactions with homeodomain proteins. Furthermore, these results suggest a link between glutamate receptors, PDZ proteins and the DLX transcription factors, all of which are co-expressed in the developing basal ganglia.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DIP2 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Distal-less homeobox proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dlx5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dlx6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GAL4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ncoa2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tes protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0165-3806
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
24
|
|
pubmed:volume |
130
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
217-30
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:11675124-Alternative Splicing,
pubmed-meshheading:11675124-Animals,
pubmed-meshheading:11675124-Arabidopsis Proteins,
pubmed-meshheading:11675124-Basal Ganglia,
pubmed-meshheading:11675124-DNA-Binding Proteins,
pubmed-meshheading:11675124-Enhancer Elements, Genetic,
pubmed-meshheading:11675124-Fungal Proteins,
pubmed-meshheading:11675124-Gene Expression Regulation, Developmental,
pubmed-meshheading:11675124-Homeodomain Proteins,
pubmed-meshheading:11675124-Mice,
pubmed-meshheading:11675124-Nuclear Receptor Coactivator 2,
pubmed-meshheading:11675124-Protein Structure, Tertiary,
pubmed-meshheading:11675124-Receptors, AMPA,
pubmed-meshheading:11675124-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:11675124-Transcription Factors,
pubmed-meshheading:11675124-Transcriptional Activation,
pubmed-meshheading:11675124-Two-Hybrid System Techniques,
pubmed-meshheading:11675124-Yeasts
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins.
|
|
pubmed:affiliation |
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, 401 Parnassus Avenue, University of California at San Francisco, CA 94143-0984, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
