Source:http://linkedlifedata.com/resource/pubmed/id/11673231
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
2001-10-23
|
pubmed:abstractText |
Whole genome shotgun sequencing strategies generate sequence data prior to the application of assembly methodologies that result in contiguous sequence. Sequence reads can be employed to indicate regions of conservation between closely related species for which only one genome has been assembled. Consequently, by using pairwise sequence alignments methods it is possible to identify novel, non-repetitive, conserved segments in non-coding sequence that exist between the assembled human genome and mouse whole genome shotgun sequencing fragments. Conserved non-coding regions identify potentially functional DNA that could be involved in transcriptional regulation.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1367-4803
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
871-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11673231-Algorithms,
pubmed-meshheading:11673231-Animals,
pubmed-meshheading:11673231-Binding Sites,
pubmed-meshheading:11673231-Computational Biology,
pubmed-meshheading:11673231-Conserved Sequence,
pubmed-meshheading:11673231-DNA,
pubmed-meshheading:11673231-Genes, Regulator,
pubmed-meshheading:11673231-Genome, Human,
pubmed-meshheading:11673231-Humans,
pubmed-meshheading:11673231-Mice,
pubmed-meshheading:11673231-Models, Genetic,
pubmed-meshheading:11673231-Sequence Alignment,
pubmed-meshheading:11673231-Sequence Analysis, DNA,
pubmed-meshheading:11673231-Transcription Factors
|
pubmed:year |
2001
|
pubmed:articleTitle |
Enrichment of regulatory signals in conserved non-coding genomic sequence.
|
pubmed:affiliation |
Informatics Research, Celera Genomics Corporation, 45 West Gude Drive, Rockville, MD 20850, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|