Source:http://linkedlifedata.com/resource/pubmed/id/11669478
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2001-10-23
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| pubmed:abstractText |
Several recent studies have investigated the association between interleukin-1 genotype and periodontitis in clinical samples, where generalizability is an issue. The aim of this study was to investigate the association between adult periodontitis and IL-1 genotype in a population-based sample of 26-year-olds. Based on probing depth (PD) measurements, participants were divided into three disease groups: "Severe" (1+ teeth with 5+mm PD; N = 25), "Moderate" (2+ teeth with 4+mm PD; N = 36), and "Controls" (the remainder; N = 800). The "periodontitis-associated genotype" (PAG; Kornman et al., 1997) was present in 20.0% of the "Severe" group and in 34.8% of "Controls", whereas the IL-1A(+4845) [1,1]/IL-1B(+3953) [2,2] genotype was present in 12.0% and 0.9%, respectively. After controlling for sex, smoking status, and plaque levels, we found that those with IL-1B(+3953) [1,1]/IL-1A(+4845) [2,2] had 12.3 times the odds of being in the "Severe" group. Analysis of these data suggests that the IL-1A(+4845) [1,1]/IL-1B(+3953) [2,2] genotype is associated with periodontal disease in this young population. Future periodontal data collections as this cohort ages are required to confirm the predictive value of that genotype.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0022-0345
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
80
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1700-3
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11669478-Adult,
pubmed-meshheading:11669478-Age Factors,
pubmed-meshheading:11669478-Analysis of Variance,
pubmed-meshheading:11669478-Cohort Studies,
pubmed-meshheading:11669478-Dental Plaque Index,
pubmed-meshheading:11669478-Female,
pubmed-meshheading:11669478-Genotype,
pubmed-meshheading:11669478-Humans,
pubmed-meshheading:11669478-Interleukin-1,
pubmed-meshheading:11669478-Logistic Models,
pubmed-meshheading:11669478-Male,
pubmed-meshheading:11669478-New Zealand,
pubmed-meshheading:11669478-Odds Ratio,
pubmed-meshheading:11669478-Periodontal Pocket,
pubmed-meshheading:11669478-Periodontitis,
pubmed-meshheading:11669478-Phenotype,
pubmed-meshheading:11669478-Population Surveillance,
pubmed-meshheading:11669478-Sensitivity and Specificity,
pubmed-meshheading:11669478-Sex Factors,
pubmed-meshheading:11669478-Smoking
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
IL-1 genotype and adult periodontitis among young New Zealanders.
|
| pubmed:affiliation |
Department of Oral Health, School of Dentistry, The University of Otago, Dunedin, New Zealand. mthomson@gandalf.otago.ac.nz
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|