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pubmed-article:11668468pubmed:abstractTextThe distinction of a primary lung carcinoma from a metastatic lesion is important, because the treatment and prognosis differ for patients with these malignancies. Such a distinction can be difficult because of overlapping cytologic features. It has been shown that antibodies to thyroid transcription factor 1 (TTF-1) and PE-10 are fairly specific markers for primary lung tumors in histologic specimens. TTF-1 regulates the expression of surfactant protein production, and PE-10 is a monoclonal antibody against components of human surfactant proteins. The combination of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) immunoprofiling has been helpful in the identification of the primary site of origin of lung tumors.lld:pubmed
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pubmed-article:11668468pubmed:copyrightInfoCopyright 2001 American Cancer Society.lld:pubmed
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pubmed-article:11668468pubmed:articleTitleUse of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens.lld:pubmed
pubmed-article:11668468pubmed:affiliationDepartment of Pathology, University of Alabama at Birmingham, 35249-6823, USA. dchhieng@path.uab.edulld:pubmed
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