|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-10-22
|
|
pubmed:abstractText |
The distinction of a primary lung carcinoma from a metastatic lesion is important, because the treatment and prognosis differ for patients with these malignancies. Such a distinction can be difficult because of overlapping cytologic features. It has been shown that antibodies to thyroid transcription factor 1 (TTF-1) and PE-10 are fairly specific markers for primary lung tumors in histologic specimens. TTF-1 regulates the expression of surfactant protein production, and PE-10 is a monoclonal antibody against components of human surfactant proteins. The combination of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) immunoprofiling has been helpful in the identification of the primary site of origin of lung tumors.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Intermediate Filament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/KRT20 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KRT7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-20,
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Keratins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactants,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/thyroid nuclear factor 1
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0008-543X
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2001 American Cancer Society.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
25
|
|
pubmed:volume |
93
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
330-6
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11668468-Adenocarcinoma,
pubmed-meshheading:11668468-Biopsy, Needle,
pubmed-meshheading:11668468-Carcinoma, Large Cell,
pubmed-meshheading:11668468-Carcinoma, Small Cell,
pubmed-meshheading:11668468-Carcinoma, Squamous Cell,
pubmed-meshheading:11668468-Humans,
pubmed-meshheading:11668468-Immunohistochemistry,
pubmed-meshheading:11668468-Intermediate Filament Proteins,
pubmed-meshheading:11668468-Keratin-20,
pubmed-meshheading:11668468-Keratin-7,
pubmed-meshheading:11668468-Keratins,
pubmed-meshheading:11668468-Lung Neoplasms,
pubmed-meshheading:11668468-Neoplasm Metastasis,
pubmed-meshheading:11668468-Nuclear Proteins,
pubmed-meshheading:11668468-Predictive Value of Tests,
pubmed-meshheading:11668468-Pulmonary Surfactants,
pubmed-meshheading:11668468-Sensitivity and Specificity,
pubmed-meshheading:11668468-Thyroid Gland,
pubmed-meshheading:11668468-Transcription Factors,
pubmed-meshheading:11668468-Tumor Markers, Biological
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Use of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens.
|
|
pubmed:affiliation |
Department of Pathology, University of Alabama at Birmingham, 35249-6823, USA. dchhieng@path.uab.edu
|
|
pubmed:publicationType |
Journal Article,
Evaluation Studies
|
