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rdf:type |
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lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0020964,
umls-concept:C0024109,
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1609432,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
11
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pubmed:dateCreated |
2001-10-30
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pubmed:abstractText |
A potent role for memory CD8+ T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1067-76
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11668342-Administration, Intranasal,
pubmed-meshheading:11668342-Animals,
pubmed-meshheading:11668342-Antigens, Viral,
pubmed-meshheading:11668342-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11668342-Cells, Cultured,
pubmed-meshheading:11668342-Cytokines,
pubmed-meshheading:11668342-Humans,
pubmed-meshheading:11668342-Immunization,
pubmed-meshheading:11668342-Immunologic Memory,
pubmed-meshheading:11668342-Interferon-gamma,
pubmed-meshheading:11668342-Lung,
pubmed-meshheading:11668342-Lymphocyte Activation,
pubmed-meshheading:11668342-Lymphocytic Choriomeningitis,
pubmed-meshheading:11668342-Lymphocytic choriomeningitis virus,
pubmed-meshheading:11668342-Male,
pubmed-meshheading:11668342-Mice,
pubmed-meshheading:11668342-Mice, Inbred C57BL,
pubmed-meshheading:11668342-Nasal Mucosa,
pubmed-meshheading:11668342-Organ Specificity,
pubmed-meshheading:11668342-Respiratory Tract Infections,
pubmed-meshheading:11668342-T-Lymphocyte Subsets,
pubmed-meshheading:11668342-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11668342-Vaccinia,
pubmed-meshheading:11668342-Vaccinia virus
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pubmed:year |
2001
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pubmed:articleTitle |
Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung.
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pubmed:affiliation |
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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