Linked Life Data

11668024

Source:http://linkedlifedata.com/resource/pubmed/id/11668024

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-10-22
pubmed:abstractText
Rats maintained with parenteral nutrition following 60% jejunoileal resection plus cecectomy exhibit minimal adaptive growth in the residual jejunum but a dramatic adaptive growth in the residual colon. Coinfusion of insulin-like growth factor I (IGF-I) with parenteral nutrition induces jejunal growth but has minimal effects in the colon. Our objective was to study the role of the endogenous IGF-I system in the differential responses of jejunum and colon to resection and/or IGF-I during parenteral nutrition. We measured concentrations of immunoreactive IGF-I in plasma, jejunum, and colon, IGF-I receptor binding, and levels of IGF receptor, IGF-I, IGF binding protein (IGFBP)-3 and IGFBP-5 mRNA in residual jejunum and colon 7 days after resection and/or IGF-I treatment. IGF-I receptor number was increased (74-99%) in jejunum and colon due to resection; IGF-I mRNA was increased 5-fold in jejunum and 15-fold in colon due to resection. Resection increased circulating IGFBPs but did not alter plasma IGF-I concentration. Resection induced colonic growth in association with significantly greater colonic IGFBP-5 mRNA and significantly lower colonic immunoreactive IGF-I. IGF-I treatment had no significant effect on IGF-I mRNA or IGF-I receptor number. Concentrations of plasma and jejunal immunoreactive IGF-I were significantly increased in rats given IGF-I in association with jejunal growth. IGF-I treatment significantly increased IGFBP-5 mRNA in the jejunum, which also correlated with jejunal growth. Thus resection upregulated IGF-I receptor number and IGF-I mRNA in residual jejunum and colon, but differential adaptation of these segments correlated with differential regulation of IGFBP-5 mRNA.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0193-1857
pubmed:author
pubmed:issnType
Print
pubmed:volume
281
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G1158-68
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11668024-Anastomosis, Surgical, pubmed-meshheading:11668024-Animals, pubmed-meshheading:11668024-Body Weight, pubmed-meshheading:11668024-Colon, pubmed-meshheading:11668024-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:11668024-Insulin-Like Growth Factor Binding Protein 5, pubmed-meshheading:11668024-Insulin-Like Growth Factor Binding Proteins, pubmed-meshheading:11668024-Insulin-Like Growth Factor I, pubmed-meshheading:11668024-Intestinal Mucosa, pubmed-meshheading:11668024-Jejunum, pubmed-meshheading:11668024-Male, pubmed-meshheading:11668024-Organ Size, pubmed-meshheading:11668024-Parenteral Nutrition, pubmed-meshheading:11668024-RNA, Messenger, pubmed-meshheading:11668024-Rats, pubmed-meshheading:11668024-Rats, Sprague-Dawley, pubmed-meshheading:11668024-Receptor, IGF Type 1, pubmed-meshheading:11668024-Up-Regulation
pubmed:year
2001
pubmed:articleTitle
Resection upregulates the IGF-I system of parenterally fed rats with jejunocolic anastomosis.
pubmed:affiliation
Department of Nutritional Sciences, University of Wisconsin-Madison, 53706, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't