Linked Life Data

1165530

Source:http://linkedlifedata.com/resource/pubmed/id/1165530

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-12-11
pubmed:abstractText
Ticarcillin, a new penicillin derivative with greater in vitro activity against Pseudomonas than carbenicillin, was given as a single dose of 50 mg/kg intramuscularly on 61 occasions to 54 neonates and young infants. The serum concentrations and rate of elimination varied considerably depending upon gestational age, chronological age, and body weight. Peak serum concentrations depended principally upon the volume of distribution which approximated the extracellular fluid volume of the neonate. The plasma clearance and serum half-life of the drug were determined. From these pharmacokinetic data appropriate groupings according to age and body weight were made and dosages and intervals of administration predicted for clinical trials of efficacy with repeated doses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3476
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
474-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Clinical pharmacology of ticarcillin in the newborn infant: relation to age, gestational age, and weight.
pubmed:publicationType
Journal Article