| pubmed-article:11641386 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11641386 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11641386 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:11641386 | lifeskim:mentions | umls-concept:C0033551 | lld:lifeskim |
| pubmed-article:11641386 | lifeskim:mentions | umls-concept:C1707391 | lld:lifeskim |
| pubmed-article:11641386 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:11641386 | lifeskim:mentions | umls-concept:C1880018 | lld:lifeskim |
| pubmed-article:11641386 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11641386 | pubmed:dateCreated | 2001-10-19 | lld:pubmed |
| pubmed-article:11641386 | pubmed:abstractText | Estrogen alters reactivity of cerebral arteries by modifying production of endothelium-dependent vasodilators. Estrogen receptors (ER) are thought to be involved, but the responsible ER subtype is unknown. ER-alpha knockout (alphaERKO) mice were used to test whether estrogen acts via ER-alpha. Mice were ovariectomized, with or without estrogen replacement, and cerebral blood vessels were isolated 1 mo later. Estrogen increased levels of endothelial nitric oxide synthase and cyclooxygenase-1 in vessels from wild-type mice but was ineffective in alphaERKO mice. Endothelium-denuded middle cerebral artery segments from all animals constricted when pressurized. In denuded arteries from alphaERKO but not wild-type mice, estrogen treatment enhanced constriction. In endothelium-intact, pressurized arteries from wild-type estrogen-treated mice, diameters were larger compared with arteries from untreated wild-type mice. In addition, contractile responses to indomethacin were greater in arteries from wild-type estrogen-treated mice compared with arteries from untreated wild-type mice. In contrast, estrogen treatment of alphaERKO mice had no effect on diameter or indomethacin responses of endothelium-intact arteries. Thus ER-alpha regulation of endothelial nitric oxide synthase and cyclooxygenase-1 pathways appears to contribute to effects of estrogen on cerebral artery reactivity. | lld:pubmed |
| pubmed-article:11641386 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11641386 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11641386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11641386 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11641386 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11641386 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:11641386 | pubmed:author | pubmed-author:DucklesS PSP | lld:pubmed |
| pubmed-article:11641386 | pubmed:author | pubmed-author:KorachK SKS | lld:pubmed |
| pubmed-article:11641386 | pubmed:author | pubmed-author:KrauseD NDN | lld:pubmed |
| pubmed-article:11641386 | pubmed:author | pubmed-author:OspinaJ AJA | lld:pubmed |
| pubmed-article:11641386 | pubmed:author | pubmed-author:GearyG GGG | lld:pubmed |
| pubmed-article:11641386 | pubmed:author | pubmed-author:McNeillA MAM | lld:pubmed |
| pubmed-article:11641386 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11641386 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:11641386 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11641386 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11641386 | pubmed:pagination | 2391-9; discussion 2389-90 | lld:pubmed |
| pubmed-article:11641386 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11641386 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11641386 | pubmed:articleTitle | Selected contribution: cerebrovascular nos and cyclooxygenase are unaffected by estrogen in mice lacking estrogen receptor-alpha. | lld:pubmed |
| pubmed-article:11641386 | pubmed:affiliation | Department of Pharmacology, College of Medicine, University of California, Irvine, California 92697-4625, USA. | lld:pubmed |
| pubmed-article:11641386 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11641386 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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