Source:http://linkedlifedata.com/resource/pubmed/id/11641386
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2001-10-19
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| pubmed:abstractText |
Estrogen alters reactivity of cerebral arteries by modifying production of endothelium-dependent vasodilators. Estrogen receptors (ER) are thought to be involved, but the responsible ER subtype is unknown. ER-alpha knockout (alphaERKO) mice were used to test whether estrogen acts via ER-alpha. Mice were ovariectomized, with or without estrogen replacement, and cerebral blood vessels were isolated 1 mo later. Estrogen increased levels of endothelial nitric oxide synthase and cyclooxygenase-1 in vessels from wild-type mice but was ineffective in alphaERKO mice. Endothelium-denuded middle cerebral artery segments from all animals constricted when pressurized. In denuded arteries from alphaERKO but not wild-type mice, estrogen treatment enhanced constriction. In endothelium-intact, pressurized arteries from wild-type estrogen-treated mice, diameters were larger compared with arteries from untreated wild-type mice. In addition, contractile responses to indomethacin were greater in arteries from wild-type estrogen-treated mice compared with arteries from untreated wild-type mice. In contrast, estrogen treatment of alphaERKO mice had no effect on diameter or indomethacin responses of endothelium-intact arteries. Thus ER-alpha regulation of endothelial nitric oxide synthase and cyclooxygenase-1 pathways appears to contribute to effects of estrogen on cerebral artery reactivity.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
8750-7587
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
91
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2391-9; discussion 2389-90
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11641386-Animals,
pubmed-meshheading:11641386-Blotting, Western,
pubmed-meshheading:11641386-Body Weight,
pubmed-meshheading:11641386-Cerebral Arteries,
pubmed-meshheading:11641386-Cyclooxygenase Inhibitors,
pubmed-meshheading:11641386-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:11641386-Endothelium, Vascular,
pubmed-meshheading:11641386-Estrogen Receptor alpha,
pubmed-meshheading:11641386-Female,
pubmed-meshheading:11641386-Male,
pubmed-meshheading:11641386-Mice,
pubmed-meshheading:11641386-Muscle, Smooth, Vascular,
pubmed-meshheading:11641386-Nitric Oxide Synthase,
pubmed-meshheading:11641386-Nitric Oxide Synthase Type II,
pubmed-meshheading:11641386-Nitric Oxide Synthase Type III,
pubmed-meshheading:11641386-Organ Size,
pubmed-meshheading:11641386-Ovariectomy,
pubmed-meshheading:11641386-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:11641386-Receptors, Estrogen,
pubmed-meshheading:11641386-Sex Characteristics
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| pubmed:year |
2001
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| pubmed:articleTitle |
Selected contribution: cerebrovascular nos and cyclooxygenase are unaffected by estrogen in mice lacking estrogen receptor-alpha.
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| pubmed:affiliation |
Department of Pharmacology, College of Medicine, University of California, Irvine, California 92697-4625, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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