Linked Life Data

11641310

Source:http://linkedlifedata.com/resource/pubmed/id/11641310

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-10-19
pubmed:abstractText
International guidelines recommend that antihypertensive drug therapy should normalize not only diastolic (DBP) but also systolic blood pressure (SBP). Therapeutic trials based on cardiovascular mortality have recently shown that SBP reduction requires normalization of both large artery stiffness and wave reflections. The aim of the present study was to compare the antihypertensive effects of the very-low-dose combination indapamide (0.625 mg) and perindopril (2 mg) (Per/Ind) with the beta-blocking agent atenolol (50 mg) to determine whether Per/Ind decreases SBP and pulse pressure (PP) more than does atenolol and, if so, whether this decrease is predominantly due to reduction of aortic pulse wave velocity (PWV) (automatic measurements) and reduction of wave reflections (pulse wave analysis, applanation tonometry). In a double-blind randomized study, 471 patients with essential hypertension were followed for 12 months. For the same DBP reduction, Per/Ind decreased brachial SBP (-6.02 mm Hg; 95% confidence interval, -8.90 to -3.14) and PP (-5.57; 95% confidence interval, -7.70 to -3.44) significantly more than did atenolol. This difference was significantly more pronounced for the carotid artery than for the brachial artery. Whereas the 2 antihypertensive agents decreased PWV to a similar degree, only Per/Ind significantly attenuated carotid wave reflections, resulting in a selective decrease in SBP and PP. The very-low-dose combination Per/Ind normalizes SBP, PP, and arterial function to a significantly larger extent than does atenolol, a hemodynamic profile that is known to improve survival in hypertensive populations with high cardiovascular risk.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
922-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11641310-Adolescent, pubmed-meshheading:11641310-Adrenergic beta-Antagonists, pubmed-meshheading:11641310-Adult, pubmed-meshheading:11641310-Aged, pubmed-meshheading:11641310-Aged, 80 and over, pubmed-meshheading:11641310-Antihypertensive Agents, pubmed-meshheading:11641310-Aorta, pubmed-meshheading:11641310-Arteries, pubmed-meshheading:11641310-Asthenia, pubmed-meshheading:11641310-Atenolol, pubmed-meshheading:11641310-Blood Pressure, pubmed-meshheading:11641310-Brachial Artery, pubmed-meshheading:11641310-Carotid Arteries, pubmed-meshheading:11641310-Cough, pubmed-meshheading:11641310-Dizziness, pubmed-meshheading:11641310-Dose-Response Relationship, Drug, pubmed-meshheading:11641310-Double-Blind Method, pubmed-meshheading:11641310-Drug Combinations, pubmed-meshheading:11641310-Follow-Up Studies, pubmed-meshheading:11641310-Headache, pubmed-meshheading:11641310-Heart Rate, pubmed-meshheading:11641310-Humans, pubmed-meshheading:11641310-Hypertension, pubmed-meshheading:11641310-Indapamide, pubmed-meshheading:11641310-Middle Aged, pubmed-meshheading:11641310-Perindopril, pubmed-meshheading:11641310-Pulse, pubmed-meshheading:11641310-Treatment Outcome
pubmed:year
2001
pubmed:articleTitle
Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: a comparison with atenolol.
pubmed:affiliation
Hôpital Broussais, Paris, France.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Multicenter Study