Source:http://linkedlifedata.com/resource/pubmed/id/11641307
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-10-19
|
| pubmed:abstractText |
Data remain insufficient to place the decreased response to L-arginine in hypertensive patients within a consistent pathophysiological sequence. The aim of the present study in patients with essential hypertension was to assess the relationships between the response to L-arginine and a set of relevant clinical and laboratory parameters. In this prospective, interventional study, we administered L-arginine to untreated hypertensive individuals and healthy control subjects and measured the clearance of inulin and of para-aminohippurate and a set of biochemical and clinical variables. L-Arginine infusion revealed major differences between control subjects and 1 subgroup (group B) of hypertensive individuals. Group B hypertensives (n=18) had no increase in inulin clearance and no decrease in renal vascular resistance with L-arginine; however, in another subset of hypertensive patients (group A, n=27), the insulin clearance increased and renal vascular resistance decreased similar to the control group (group C, n=11). The ambulatory blood pressure monitoring in group B showed both an increased mean diastolic pressure and a "nondipper" pattern in the nocturnal regulation of arterial pressure. These findings in group B were accompanied by significant alterations in optic fundus and left ventricle hypertrophy and increased microalbuminuria (all, P<0.05). Furthermore, group B individuals had significantly lower values of HDL cholesterol and a higher baseline atherogenic index, plasma insulin level, and glucose/insulin index. We disclose a previously undescribed relationship between end organ repercussion and decreased renal hemodynamic response to L-arginine. Our results may help to understand the mechanisms that lead to target organ damage in hypertension.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1524-4563
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| pubmed:author |
pubmed-author:AlcázarJ MJM,
pubmed-author:BelloEE,
pubmed-author:CarameloCC,
pubmed-author:CasadoSS,
pubmed-author:GazapoRR,
pubmed-author:GonzálezF RFR,
pubmed-author:GonzálezJJ,
pubmed-author:LópezM DMD,
pubmed-author:MartellNN,
pubmed-author:RoviraA MAM,
pubmed-author:RuilopeL MLM,
pubmed-author:SoldevillaM JMJ
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
907-12
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11641307-Adult,
pubmed-meshheading:11641307-Albuminuria,
pubmed-meshheading:11641307-Arginine,
pubmed-meshheading:11641307-Blood Pressure,
pubmed-meshheading:11641307-Cholesterol, HDL,
pubmed-meshheading:11641307-Electrocardiography,
pubmed-meshheading:11641307-Female,
pubmed-meshheading:11641307-Glomerular Filtration Rate,
pubmed-meshheading:11641307-Heart Ventricles,
pubmed-meshheading:11641307-Humans,
pubmed-meshheading:11641307-Hypertension,
pubmed-meshheading:11641307-Inulin,
pubmed-meshheading:11641307-Kidney,
pubmed-meshheading:11641307-Male,
pubmed-meshheading:11641307-Middle Aged,
pubmed-meshheading:11641307-Renal Circulation,
pubmed-meshheading:11641307-Vascular Resistance,
pubmed-meshheading:11641307-Vasodilation,
pubmed-meshheading:11641307-p-Aminohippuric Acid
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Impairment of renal vasodilation with l-arginine is related to more severe disease in untreated hypertensive patients.
|
| pubmed:affiliation |
Instituto de Investigaciones Médicas, Fundación Jiménez Díaz, Hypertension Units, Hospital Clínico de San Carlos, Universidad Autónoma, Madrid, Spain.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|