Source:http://linkedlifedata.com/resource/pubmed/id/11640993
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-10-19
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| pubmed:abstractText |
The aim of this study was to investigate whether an association exists between the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and microvascular complications of type 2 diabetes mellitus in Turkish patients. A total of 239 type 2 diabetic patients and 138 sex and age matched control subjects were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). Nephropathy status was determined according to urinary albumin/creatinine ratio (microg/mg) (<30 normoalbuminuria, 30-300 microalbuminuria, >300 macroalbuminuria) and retinopathy was evaluated by fundoscopic examination and by flourescein fundus angiography. The distribution of ACE I/D polymorphism and allele frequencies in diabetic patients were not significantly different from controls, DD genotype 32.2 versus 37.2%; ID genotype 50.6 versus 47.1%; and II 17.2 versus 15.2%; D allele 57.5 versus 61.2%; I allele 42.5 versus 38.8%. Genotype distribution between normo-, micro- and macroalbuminuric patients did not differ significantly (DD:ID:II (%), normoalbuminuria, 35:46:19; microalbuminuria, 28:55:17; macroalbuminuria, 31:55:14). There was also no difference in genotype distribution between patients with and without retinopathy (DD:ID:II (%), retinopathy positive, 32:51:17; retinopathy negative, 33:49:18). In conclusion, the ACE I/D polymorphism does not seem to be associated with diabetic nephropathy and retinopathy in Turkish type 2 diabetic patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0168-8227
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
54
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
95-104
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11640993-Adult,
pubmed-meshheading:11640993-Aged,
pubmed-meshheading:11640993-Albuminuria,
pubmed-meshheading:11640993-Blood Pressure,
pubmed-meshheading:11640993-Cholesterol,
pubmed-meshheading:11640993-Cholesterol, HDL,
pubmed-meshheading:11640993-Cholesterol, LDL,
pubmed-meshheading:11640993-DNA Primers,
pubmed-meshheading:11640993-Diabetes Mellitus, Type 2,
pubmed-meshheading:11640993-Diabetic Angiopathies,
pubmed-meshheading:11640993-Diabetic Nephropathies,
pubmed-meshheading:11640993-Female,
pubmed-meshheading:11640993-Hemoglobin A, Glycosylated,
pubmed-meshheading:11640993-Humans,
pubmed-meshheading:11640993-Male,
pubmed-meshheading:11640993-Middle Aged,
pubmed-meshheading:11640993-Peptidyl-Dipeptidase A,
pubmed-meshheading:11640993-Polymorphism, Genetic,
pubmed-meshheading:11640993-Triglycerides,
pubmed-meshheading:11640993-Turkey
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| pubmed:year |
2001
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| pubmed:articleTitle |
Angiotensin-converting enzyme gene polymorphism and microvascular complications in Turkish type 2 diabetic patients.
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| pubmed:affiliation |
Department of Internal Medicine, Medical Faculty, Gaziantep University, TR-27070, Gaziantep, Turkey. araz@gantep.edu.tr
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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