Linked Life Data

1163832

Source:http://linkedlifedata.com/resource/pubmed/id/1163832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-12-4
pubmed:abstractText
Pulmonary and renal excretion of isoflurane and its metabolites was studied in nine surgical patients following administration of known quantitities of isoflurane. Uptake and pulmonary washout were predictable by a mathematical model for inert vapors. The agreement between predicted and experimental data supports the view that isoflurane is subject to little or no biotransformation. The average recovery in exhaled air was 95 per cent, SE 7 per cent. The postoperative increase of urinary excretion of fluoride and organic fluorine accounted for less than 0.2 per cent of fluorine administered as isoflurane. This small extent of biotransformation is probably biologically insignificant, but only after extensive clinical experience can the hazard of delayed toxic response be conclusively evaluated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Resistance of isoflurane to biotransformation in man.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.