Linked Life Data

1163653

Source:http://linkedlifedata.com/resource/pubmed/id/1163653

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1975-11-25
pubmed:abstractText
Calcium metabolism was studied in growing rats, submitted to calcium deprivation ofvarious intensity. A decreased intake resulted in decreased net absorption of calcium(V'na), no change in bone formation (V'o+), and an increase in bone resorption (V'o -). In animals given dichloromethylene disphosphate (Cl'2MDP), a compoundknown to inhibit bone resorption, V'o+ was less than in the controls but again the same at all calcium intakes; V'na was below V'o+, V'o- still increased as the calcium intake was reduced. The various kinetic parameters in rats receiving Cl'2MDPwere indistinguishable from published data in parathyroidectomized (PTX) animals, yetblood calcium was low in PTX rats but normal in Cl'2MDP-atreated rats. It appears that the rat has an efficient mechanism for increasing bone resorption which is not inhibited by Cl'2MDP and does not require parathyroid hormone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
228
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1750-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Effects of a diphophonate on calcium metabolism in calcium-deprived rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.