Source:http://linkedlifedata.com/resource/pubmed/id/11607789
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2001-10-18
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| pubmed:abstractText |
The cytokine receptor family type 2 (CRF2) comprises receptors for important immunomediators like interferons and interleukin-10 (IL-10). We identified a novel member of this family which represents the first exclusively soluble receptor in this group and was therefore designated as CRF2-soluble 1 (CRF2-s1). The CRF2-s1 gene covers about 28 kb and is located on chromosome 6 in close proximity to the CRF2 members interferon (IFN)-gamma receptor 1 and IL-20 receptor 1. It comprises seven exons and generates two different mRNA splice variants, CRF2-s1-long and CRF2-s1-short. CRF2-s1-long and CRF2-s1-short encode proteins of 263 and 231 amino acids, respectively. A comparison of predicted protein structures led to the postulation that each receptor variants binds a different ligand. Quantitative analysis of human mRNA expression revealed a very restricted pattern for both splice forms. CRF2-s1 turned out to be the first member of this receptor family which was expressed neither in resting nor in stimulated leucocyte populations. CRF2-s1-long was only expressed in placenta, whereas CRF2-s1-short was additionally expressed in human mammary gland and, at a lower level, in skin, spleen, thymus and stomach. The preferential expression of CRF2-s1 in placenta suggests a role for this receptor in establishing and maintaining successful pregnancy.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1466-4879
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
2
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
329-34
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11607789-Amino Acid Sequence,
pubmed-meshheading:11607789-Base Sequence,
pubmed-meshheading:11607789-Chromosomes, Human, Pair 6,
pubmed-meshheading:11607789-Computational Biology,
pubmed-meshheading:11607789-Databases, Genetic,
pubmed-meshheading:11607789-Exons,
pubmed-meshheading:11607789-Female,
pubmed-meshheading:11607789-Flow Cytometry,
pubmed-meshheading:11607789-Gene Expression Profiling,
pubmed-meshheading:11607789-Humans,
pubmed-meshheading:11607789-Introns,
pubmed-meshheading:11607789-Leukocytes,
pubmed-meshheading:11607789-Molecular Sequence Data,
pubmed-meshheading:11607789-Organ Specificity,
pubmed-meshheading:11607789-Physical Chromosome Mapping,
pubmed-meshheading:11607789-Placenta,
pubmed-meshheading:11607789-RNA, Messenger,
pubmed-meshheading:11607789-Receptors, Cytokine,
pubmed-meshheading:11607789-Receptors, Interleukin,
pubmed-meshheading:11607789-Receptors, Interleukin-10,
pubmed-meshheading:11607789-Sequence Homology, Amino Acid,
pubmed-meshheading:11607789-Solubility
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| pubmed:year |
2001
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| pubmed:articleTitle |
A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta.
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| pubmed:affiliation |
Department of Experimental Dermatology, Schering AG, D-13342 Berlin, Germany.
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| pubmed:publicationType |
Journal Article
|