Linked Life Data

11606625

Source:http://linkedlifedata.com/resource/pubmed/id/11606625

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2001-10-18
pubmed:abstractText
Inflammation in Alzheimer's disease (AD) patients is characterized by increased cytokines and activated microglia. Epidemiological studies suggest reduced AD risk associates with long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). Whereas chronic ibuprofen suppressed inflammation and plaque-related pathology in an Alzheimer transgenic APPSw mouse model (Tg2576), excessive use of NSAIDs targeting cyclooxygenase I can cause gastrointestinal, liver, and renal toxicity. One alternative NSAID is curcumin, derived from the curry spice turmeric. Curcumin has an extensive history as a food additive and herbal medicine in India and is also a potent polyphenolic antioxidant. To evaluate whether it could affect Alzheimer-like pathology in the APPSw mice, we tested a low (160 ppm) and a high dose of dietary curcumin (5000 ppm) on inflammation, oxidative damage, and plaque pathology. Low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of these mice. With low-dose but not high-dose curcumin treatment, the astrocytic marker GFAP was reduced, and insoluble beta-amyloid (Abeta), soluble Abeta, and plaque burden were significantly decreased by 43-50%. However, levels of amyloid precursor (APP) in the membrane fraction were not reduced. Microgliosis was also suppressed in neuronal layers but not adjacent to plaques. In view of its efficacy and apparent low toxicity, this Indian spice component shows promise for the prevention of Alzheimer's disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8370-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11606625-Alzheimer Disease, pubmed-meshheading:11606625-Amyloid, pubmed-meshheading:11606625-Amyloid beta-Peptides, pubmed-meshheading:11606625-Animals, pubmed-meshheading:11606625-Antioxidants, pubmed-meshheading:11606625-Brain, pubmed-meshheading:11606625-Curcumin, pubmed-meshheading:11606625-Disease Models, Animal, pubmed-meshheading:11606625-Dose-Response Relationship, Drug, pubmed-meshheading:11606625-Encephalitis, pubmed-meshheading:11606625-Enzyme Inhibitors, pubmed-meshheading:11606625-Female, pubmed-meshheading:11606625-Glial Fibrillary Acidic Protein, pubmed-meshheading:11606625-Interleukin-1, pubmed-meshheading:11606625-Male, pubmed-meshheading:11606625-Mice, pubmed-meshheading:11606625-Mice, Transgenic, pubmed-meshheading:11606625-Microglia, pubmed-meshheading:11606625-Oxidation-Reduction, pubmed-meshheading:11606625-Oxidative Stress, pubmed-meshheading:11606625-Solubility, pubmed-meshheading:11606625-Spices
pubmed:year
2001
pubmed:articleTitle
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.
pubmed:affiliation
Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't