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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-10-18
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pubmed:abstractText |
Crohn's disease (CD) is associated with an increased number of infiltrating macrophages, which release a variety of proinflammatory cytokines. Interleukin (IL)-18 has been implicated in the modulation of mucosal CD4(+) T cells towards Th1 responses, which are implicated in the pathogenesis of CD. Here we assess the role of macrophages and of IL-18 in the murine model of intestinal inflammation that mimics the immunologic characteristics of human CD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:AkiraSS,
pubmed-author:HibiTT,
pubmed-author:IiyamaRR,
pubmed-author:IkedaMM,
pubmed-author:IshiiHH,
pubmed-author:KanaiTT,
pubmed-author:KurimotoMM,
pubmed-author:OkamotoRR,
pubmed-author:OkamotoSS,
pubmed-author:OkazawaAA,
pubmed-author:SatoTT,
pubmed-author:TakedaKK,
pubmed-author:TotsukaTT,
pubmed-author:WatanabeMM,
pubmed-author:YamazakiMM
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pubmed:issnType |
Print
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
875-88
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11606501-Animals,
pubmed-meshheading:11606501-Antibodies,
pubmed-meshheading:11606501-Colitis,
pubmed-meshheading:11606501-Crohn Disease,
pubmed-meshheading:11606501-Disease Models, Animal,
pubmed-meshheading:11606501-Humans,
pubmed-meshheading:11606501-Inflammation,
pubmed-meshheading:11606501-Interleukin-18,
pubmed-meshheading:11606501-Intestinal Mucosa,
pubmed-meshheading:11606501-Macrophages,
pubmed-meshheading:11606501-Mice,
pubmed-meshheading:11606501-Mice, Inbred C57BL,
pubmed-meshheading:11606501-Mice, Knockout,
pubmed-meshheading:11606501-Trinitrobenzenesulfonic Acid
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pubmed:year |
2001
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pubmed:articleTitle |
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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