Source:http://linkedlifedata.com/resource/pubmed/id/11606141
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
|
| pubmed:dateCreated |
2001-10-18
|
| pubmed:abstractText |
A new 7,8-methylenedioxy analogue (4) of (+)-porothramycin B (2) and its water-soluble sodium bisulfite derivative (15) have been synthesized in high yields and have been shown to exhibit high cytotoxic activities against several tumor cell lines. The new pyrrolo[2,1-c][1,4]benzodiazepine 4 was as effective against the resistant cell lines as against the doxorubicin-sensitive cell lines tested.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3754-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11606141-Anthramycin,
pubmed-meshheading:11606141-Antineoplastic Agents,
pubmed-meshheading:11606141-Doxorubicin,
pubmed-meshheading:11606141-Drug Resistance, Neoplasm,
pubmed-meshheading:11606141-Drug Screening Assays, Antitumor,
pubmed-meshheading:11606141-Humans,
pubmed-meshheading:11606141-Stereoisomerism,
pubmed-meshheading:11606141-Structure-Activity Relationship,
pubmed-meshheading:11606141-Tumor Cells, Cultured
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin.
|
| pubmed:affiliation |
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France. nicole.langlois@icsn.cnrs-gif.fr
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|