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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0020792,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0449432,
umls-concept:C0521447,
umls-concept:C0679058,
umls-concept:C0679622,
umls-concept:C0812382,
umls-concept:C1179435,
umls-concept:C1416642,
umls-concept:C1522790,
umls-concept:C1524073,
umls-concept:C1547699,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C2700640
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pubmed:issue |
5 Pt 1
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pubmed:dateCreated |
2001-10-17
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pubmed:abstractText |
Ionizing radiation elicits a genetic response in human cells that allows cell survival. The human KIN (also known as KIN17) gene encodes a 45-kDa nuclear DNA-binding protein that participates in the response to UVC radiation and is immunologically related to the bacterial RecA protein. We report for the first time that ionizing radiation and bleomycin, a radiomimetic drug, which produce single- and double-strand breaks, increased expression of KIN in human cells established from tumors, including MeWo melanoma, MCF7 breast adenocarcinoma, and ATM+ GM3657 lymphoblast cells. KIN expression increased rapidly in a dose-dependent manner after irradiation. Under the same conditions, several genes controlled by TP53 were induced with kinetics similar to that of KIN. Using the CDKN1A gene as a marker of TP53 responsiveness, we analyzed the up-regulation of KIN and showed that is independent of the status of TP53 and ATM. In contrast, the presence of a dominant mutant for activating transcription factor 2 (ATF2) completely abolished the up-regulation of KIN. Our results suggest a role for ATF2 in the TP53-independent increase in KIN expression after gamma irradiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bleomycin,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/KIN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0033-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
535-44
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11604067-Activating Transcription Factor 2,
pubmed-meshheading:11604067-Bleomycin,
pubmed-meshheading:11604067-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:11604067-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:11604067-Cyclins,
pubmed-meshheading:11604067-DNA Damage,
pubmed-meshheading:11604067-DNA-Binding Proteins,
pubmed-meshheading:11604067-Gamma Rays,
pubmed-meshheading:11604067-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11604067-Humans,
pubmed-meshheading:11604067-Nuclear Proteins,
pubmed-meshheading:11604067-RNA-Binding Proteins,
pubmed-meshheading:11604067-Transcription Factors,
pubmed-meshheading:11604067-Tumor Cells, Cultured,
pubmed-meshheading:11604067-Tumor Suppressor Protein p53
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pubmed:year |
2001
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pubmed:articleTitle |
Identification of KIN (KIN17), a human gene encoding a nuclear DNA-binding protein, as a novel component of the TP53-independent response to ionizing radiation.
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pubmed:affiliation |
Laboratoire de Génétique de la Radiosensibilité, Direction des Sciences du Vivant, Centre d'Etudes de Fontenay-aux-Roses, CEA, 60-68, Avenue du Général-Leclerc, B.P. no. 6, 92265 Fontenay-aux-Roses Cedex, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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