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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-10-16
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pubmed:abstractText |
Attempts to achieve immunological tolerance to porcine tissues in nonhuman primates through establishment of mixed hematopoietic chimerism are hindered by the rapid clearance of mobilized porcine leukocytes, containing progenitor cells (pPBPCs), from the circulation. Eighteen hours after infusing 1-2 x 10(10) pPBPC/kg into baboons that had been depleted of circulating anti-alphaGal and complement, these cells are almost undetectable by flow cytometry. The aim of the present study was to identify mechanisms that contribute to rapid clearance of pPBPCs in the baboon. This was achieved by depleting, or blocking the Fc-receptors of, cells of the phagocytic reticuloendothelial system (RES) using medronate liposomes (MLs) or intravenous immunoglobulin (IVIg), respectively.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0041-1337
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pubmed:author |
pubmed-author:AbrahamSS,
pubmed-author:AlwaynI PIP,
pubmed-author:AwwadMM,
pubmed-author:BaskerMM,
pubmed-author:BuhlerLL,
pubmed-author:CooperD KDK,
pubmed-author:DeAngelisHH,
pubmed-author:DownJJ,
pubmed-author:HarperDD,
pubmed-author:Kruger GrayHH,
pubmed-author:RiebelTT,
pubmed-author:SachsD HDH,
pubmed-author:ThaleJJ,
pubmed-author:White-ScharfM EME
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1278-85
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11602856-Animals,
pubmed-meshheading:11602856-Blood Cell Count,
pubmed-meshheading:11602856-Dose-Response Relationship, Drug,
pubmed-meshheading:11602856-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11602856-Hematopoietic Stem Cells,
pubmed-meshheading:11602856-Immunoglobulins, Intravenous,
pubmed-meshheading:11602856-Leukocyte Count,
pubmed-meshheading:11602856-Liposomes,
pubmed-meshheading:11602856-Macrophages,
pubmed-meshheading:11602856-Mononuclear Phagocyte System,
pubmed-meshheading:11602856-Papio,
pubmed-meshheading:11602856-Phagocytosis,
pubmed-meshheading:11602856-Receptors, Fc,
pubmed-meshheading:11602856-Swine,
pubmed-meshheading:11602856-Time Factors,
pubmed-meshheading:11602856-Transplantation, Heterologous,
pubmed-meshheading:11602856-Transplantation Conditioning
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pubmed:year |
2001
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pubmed:articleTitle |
Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons.
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pubmed:affiliation |
Transplantation Biology Research Center, Massachusetts General Hospital / Harvard Medical School, Boston 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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