Source:http://linkedlifedata.com/resource/pubmed/id/11602792
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 11
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| pubmed:dateCreated |
2001-10-16
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| pubmed:abstractText |
Neutralization capsid epitopes are important determinants for antibody-mediated immune protection against papillomavirus (PV) infection and induced disease. Chimeric L1 major capsid proteins of the human PV type 16 (HPV-16) and the bovine PV type 1 (BPV-1) with a foreign peptide incorporated into several capsid surface loops self-assembled into pentamers or virus-like particles (VLP). Binding patterns of neutralizing monoclonal antibodies (MAb) and immunization of mice confirmed (i) that regions around aa 282-286 and 351-355 contribute to neutralization epitopes and identified the latter region as an immunodominant site and (ii) that placing a foreign peptide in the context of an assembled structure markedly enhanced its immunogenicity. Pentamers disassembled from wild-type HPV-16 and BPV-1 VLPs displayed some of the neutralization epitopes that were detected on fully assembled VLPs, but were deficient for binding a subset of neutralizing MAb that inhibit cell attachment.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Vaccines
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
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| pubmed:issn |
0022-1317
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
82
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2799-804
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11602792-Animals,
pubmed-meshheading:11602792-Antibodies, Monoclonal,
pubmed-meshheading:11602792-Antibodies, Viral,
pubmed-meshheading:11602792-Bovine papillomavirus 1,
pubmed-meshheading:11602792-Capsid,
pubmed-meshheading:11602792-Cattle,
pubmed-meshheading:11602792-Humans,
pubmed-meshheading:11602792-Immunization,
pubmed-meshheading:11602792-Immunodominant Epitopes,
pubmed-meshheading:11602792-Mice,
pubmed-meshheading:11602792-Mice, Inbred BALB C,
pubmed-meshheading:11602792-Neutralization Tests,
pubmed-meshheading:11602792-Papillomaviridae,
pubmed-meshheading:11602792-Papillomavirus Infections,
pubmed-meshheading:11602792-Recombinant Fusion Proteins,
pubmed-meshheading:11602792-Tumor Virus Infections,
pubmed-meshheading:11602792-Viral Vaccines,
pubmed-meshheading:11602792-Virion
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Chimeric papillomavirus-like particles expressing a foreign epitope on capsid surface loops.
|
| pubmed:affiliation |
Laboratory of Viral Oncology, Division of Immunology, Allergy and Infectious Diseases (DIAID), University of Vienna Medical School, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|