| pubmed-article:11600678 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11600678 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11600678 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11600678 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:11600678 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:11600678 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11600678 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:11600678 | pubmed:issue | Pt 2 | lld:pubmed |
| pubmed-article:11600678 | pubmed:dateCreated | 2001-10-15 | lld:pubmed |
| pubmed-article:11600678 | pubmed:abstractText | 1. Cellular responses to GABA(A) receptor activation were studied in developing cerebellar Purkinje neurones (PNs) in brain slices obtained from 2- to 22-day-old rats. Two-photon fluorescence imaging of fura-2-loaded cells and perforated-patch recordings were used to monitor intracellular Ca2+ transients and to estimate the reversal potential of GABA-induced currents, respectively. 2. During the 1st postnatal week, focal application of GABA or the GABA(A) receptor agonist muscimol evoked transient increases in [Ca2+]i in immature PNs. These Ca2+ transients were reversibly abolished by the GABA(A) receptor antagonist bicuculline and by Ni2+, a blocker of voltage-activated Ca2+ channels. 3. Perforated-patch recordings were used to measure the reversal potential of GABA-evoked currents (E(GABA)) at different stages of development. It was found that E(GABA) was about -44 mV at postnatal day 3 (P3), it shifted to gradually more negative values during the 1st week and finally equilibrated at -87 mV at around the end of the 2nd postnatal week. This transition was well described by a sigmoidal function. The largest change in E(GABA) was -7 mV x day(-1), which occurred at around P6. 4. The transition in GABA-mediated signalling occurs during a period in which striking changes in PN morphology and synaptic connectivity are known to take place. Since such changes were shown to be Ca2+ dependent, we propose that GABA-evoked Ca2+ signalling is one of the critical determinants for the normal development of cerebellar PNs. | lld:pubmed |
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| pubmed-article:11600678 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11600678 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11600678 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11600678 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11600678 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:11600678 | pubmed:author | pubmed-author:EilersJJ | lld:pubmed |
| pubmed-article:11600678 | pubmed:author | pubmed-author:KonnerthAA | lld:pubmed |
| pubmed-article:11600678 | pubmed:author | pubmed-author:PlantT DTD | lld:pubmed |
| pubmed-article:11600678 | pubmed:author | pubmed-author:MarandiNN | lld:pubmed |
| pubmed-article:11600678 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11600678 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11600678 | pubmed:volume | 536 | lld:pubmed |
| pubmed-article:11600678 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11600678 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11600678 | pubmed:pagination | 429-37 | lld:pubmed |
| pubmed-article:11600678 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11600678 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11600678 | pubmed:articleTitle | GABA-mediated Ca2+ signalling in developing rat cerebellar Purkinje neurones. | lld:pubmed |
| pubmed-article:11600678 | pubmed:affiliation | Abteilung Neurophysiologie, Max-Planck-Institut für Hirnforschung, 60528 Frankfurt, Germany. eilers@mpih-frankfurt.mpg.de | lld:pubmed |
| pubmed-article:11600678 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11600678 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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