Linked Life Data

11600181

Source:http://linkedlifedata.com/resource/pubmed/id/11600181

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pubmed-article:11600181pubmed:abstractTextHeterosexual transmission of human immunodeficiency virus (HIV-1) is the predominant mode of infection world-wide. To better understand sexual transmission of HIV-1 in women we have analysed virus co-receptor and cellular activation marker expression on T lymphocyte subsets from the cervical epithelium and have made comparisons with peripheral blood T cells. Intraepithelial cervical T lymphocytes were obtained with a cytobrush, immunolabelled and analysed by flow cytometry. Activation markers (CD69, CD25 and HLA-DR) were found to be more highly expressed on cervical than on blood T lymphocytes. These higher levels of activation on cervical T lymphocyte subsets could facilitate HIV-1 infection. CXCR4 was expressed at marginally higher levels than CCR5 on T cells from the cervical epithelium and peripheral blood. Thus, the preferential transmission of macrophage tropic strains of HIV-1 following sexual contact cannot be explained solely on the expression of chemokine co-receptors by T lymphocyte subsets.lld:pubmed
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pubmed-article:11600181pubmed:pagination101-11lld:pubmed
pubmed-article:11600181pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:11600181pubmed:articleTitleHigher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women.lld:pubmed
pubmed-article:11600181pubmed:affiliationDepartment of Immunology, Imperial College of Science Technology and Medicine (ICSTM) at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK.lld:pubmed
pubmed-article:11600181pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11600181pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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