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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-10-15
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pubmed:abstractText |
Heterosexual transmission of human immunodeficiency virus (HIV-1) is the predominant mode of infection world-wide. To better understand sexual transmission of HIV-1 in women we have analysed virus co-receptor and cellular activation marker expression on T lymphocyte subsets from the cervical epithelium and have made comparisons with peripheral blood T cells. Intraepithelial cervical T lymphocytes were obtained with a cytobrush, immunolabelled and analysed by flow cytometry. Activation markers (CD69, CD25 and HLA-DR) were found to be more highly expressed on cervical than on blood T lymphocytes. These higher levels of activation on cervical T lymphocyte subsets could facilitate HIV-1 infection. CXCR4 was expressed at marginally higher levels than CCR5 on T cells from the cervical epithelium and peripheral blood. Thus, the preferential transmission of macrophage tropic strains of HIV-1 following sexual contact cannot be explained solely on the expression of chemokine co-receptors by T lymphocyte subsets.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:issn |
0165-0378
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-11
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11600181-Adult,
pubmed-meshheading:11600181-Antigens, CD,
pubmed-meshheading:11600181-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:11600181-Biological Markers,
pubmed-meshheading:11600181-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11600181-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11600181-Cell Membrane,
pubmed-meshheading:11600181-Cervix Uteri,
pubmed-meshheading:11600181-Female,
pubmed-meshheading:11600181-Flow Cytometry,
pubmed-meshheading:11600181-HLA-DR Antigens,
pubmed-meshheading:11600181-Health Status,
pubmed-meshheading:11600181-Humans,
pubmed-meshheading:11600181-Lectins, C-Type,
pubmed-meshheading:11600181-Leukocytes, Mononuclear,
pubmed-meshheading:11600181-Lymphocyte Activation,
pubmed-meshheading:11600181-Receptors, CCR5,
pubmed-meshheading:11600181-Receptors, CXCR4,
pubmed-meshheading:11600181-Receptors, Interleukin-2
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pubmed:articleTitle |
Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women.
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pubmed:affiliation |
Department of Immunology, Imperial College of Science Technology and Medicine (ICSTM) at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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