11599068

Source:http://linkedlifedata.com/resource/pubmed/id/11599068

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012222, umls-concept:C0024485, umls-concept:C0025329, umls-concept:C0205419, umls-concept:C0444706, umls-concept:C0567498, umls-concept:C1707429
pubmed:issue	4
pubmed:dateCreated	2001-10-12
pubmed:abstractText	Recent investigations have shown that tumors may be distinguished from benign lesions in the breast based on differences in apparent diffusion coefficient (ADC) values. The goal of this study was to assess the magnitude of normal variations in the measured ADC of breast parenchyma during the menstrual cycle. Eight healthy female subjects were scanned once a week for 4 weeks, using a diffusion-weighted single-shot fast spin-echo (DW-SSFSE) sequence. The ADC of breast fibroglandular tissue was calculated for each woman at each time point. Results showed a trend of decreased ADC during the second week of the cycle, and increased ADC during the final week. However, no significant influence of menstrual cycle on breast ADC values was identified. The results of this study show that the normal fluctuation of breast ADC is relatively small, and the coefficient of variation was determined to be 5.5% for our group of volunteers during a menstrual cycle. Nonetheless, breast diffusion measurements for tumor differentiation and evaluation of treatment response should be interpreted with consideration of normal variability.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01-CA69587
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9105850
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	1053-1807
pubmed:author	pubmed-author:HenryR GRG, pubmed-author:HyltonN MNM, pubmed-author:McKinnonG CGC, pubmed-author:PartridgeS CSC
pubmed:copyrightInfo	Copyright 2001 Wiley-Liss, Inc.
pubmed:issnType	Print
pubmed:volume	14
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	433-8
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:11599068-Adult, pubmed-meshheading:11599068-Breast, pubmed-meshheading:11599068-Diffusion, pubmed-meshheading:11599068-Female, pubmed-meshheading:11599068-Humans, pubmed-meshheading:11599068-Magnetic Resonance Imaging, pubmed-meshheading:11599068-Menstrual Cycle
pubmed:year	2001
pubmed:articleTitle	Menstrual cycle variation of apparent diffusion coefficients measured in the normal breast using MRI.
pubmed:affiliation	Magnetic Resonance Science Center, Department of Radiology, University of California-San Francisco, 1 Irving Street, San Francisco, CA 94143-1290, USA. scpartr@mrsc.ucsf.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.