Linked Life Data

11598440

Source:http://linkedlifedata.com/resource/pubmed/id/11598440

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-10-12
pubmed:abstractText
Because of increased leasure time, the growing popularity of staying outdoors and of holidays in the sun, it has become more and more important to study the molecular and photobiological effects that ultraviolet (UV) radiation exerts on human skin. Information obtained from these studies is being used to constantly improve the quality of sunscreen preparations containing organic and inorganic filters. It is also fostering the development of antioxidants and active agents that can be used in combination with or in addition to UV filters to provide better photoprotection for human skin. In addition, these studies provide novel test models which allow to prove or disprove the efficacy of a given sunscreen preparation for biological endpoints that differ from the sunburn reaction and are of direct relevance for photocarcinogenesis and photoaging. In this review, two examples are given to illustrate this development: (1) the use of topically applied DNA repair enzymes to prevent UVB-radiation-induced damage and (2) the development of a novel assay that is based on the detection of UVA-radiation-induced mutations in mitochondrial DNA and can be used to study the efficacy of protective measures against photoaging of human skin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1422-2868
pubmed:author
pubmed:copyrightInfo
Copyright 2001 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
401-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
New developments in photoprotection of human skin.
pubmed:affiliation
Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Düsseldorf, Germany. krutmann@rz.uni-duesseldorf.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't