Source:http://linkedlifedata.com/resource/pubmed/id/11597949
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2001-10-12
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pubmed:abstractText |
Clinical trials with vitamin E have yielded contrasting results. In these trials, the amount of vitamin E given was different, and the compliance was not assessed in all studies. In addition, the modality of intake, ie, in relation to food, was not specified in any trial. Vitamin E is lipophilic, and its absorption is expected to be increased by food. We studied the bioavailability of vitamin E in relation to food intake and the effect on the lipid peroxide-scavenging activity of plasma and on 7beta-hydroxycholesterol and 7-ketocholesterol (oxysterols) as markers of oxidant stress. Twenty healthy Italian subjects were randomly assigned to take vitamin E at 300 mg/d on an empty stomach (group A) or during dinner (group B) for 15 days. Plasma vitamin E markedly increased in group B (84%) compared with group A (29%). The lipid peroxide-scavenging activity of plasma increased significantly in group B (14%, P=0.005) but did not change in group A. All subjects showed very low levels of plasma oxysterols, which were not affected by vitamin E supplementation in either group. This study shows that plasma concentration of vitamin E and plasma antioxidant activity in response to oral supplementation are markedly affected by food intake. Healthy Italian subjects show very low levels of cholesterol oxidation products; these low levels are possibly related to the Mediterranean diet. To obtain maximal absorption, vitamin E must be given at meals. These data should be taken into account in clinical trials with vitamin E.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-ketocholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxycholesterols,
http://linkedlifedata.com/resource/pubmed/chemical/Ketocholesterols,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Peroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/cholest-5-en-3 beta,7 alpha-diol
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4636
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E34-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11597949-Adult,
pubmed-meshheading:11597949-Arteriosclerosis,
pubmed-meshheading:11597949-Biological Markers,
pubmed-meshheading:11597949-Eating,
pubmed-meshheading:11597949-Female,
pubmed-meshheading:11597949-Humans,
pubmed-meshheading:11597949-Hydroxycholesterols,
pubmed-meshheading:11597949-Ketocholesterols,
pubmed-meshheading:11597949-Lipid Peroxides,
pubmed-meshheading:11597949-Male,
pubmed-meshheading:11597949-Oxidative Stress,
pubmed-meshheading:11597949-Vitamin E
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pubmed:year |
2001
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pubmed:articleTitle |
Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products.
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pubmed:affiliation |
Dipartimento di Medicina Interna, Istituto di Terapia Medica Sistematica, Università La Sapienza, Rome, Italy. luigi.iuliano@uniroma1.it
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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