Source:http://linkedlifedata.com/resource/pubmed/id/11597413
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
2001-10-12
|
| pubmed:abstractText |
Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:Abou-KhalilEE,
pubmed-author:BeaulieuCC,
pubmed-author:BestermanJJ,
pubmed-author:BouchainGG,
pubmed-author:DelormeDD,
pubmed-author:FournelMM,
pubmed-author:FrechetteSS,
pubmed-author:LavoieRR,
pubmed-author:LeisTT,
pubmed-author:MASS,
pubmed-author:Trachy-BourgetM CMC,
pubmed-author:WanR TRT,
pubmed-author:WooS HSH
|
| pubmed:issnType |
Print
|
| pubmed:day |
5
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2847-50
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading | |
| pubmed:year |
2001
|
| pubmed:articleTitle |
Design and synthesis of a novel class of histone deacetylase inhibitors.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, MethylGene Inc., 7220 Frederick-Banting, Montréal, Québec, Canada H4S 2A1.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|