Linked Life Data

11596292

Source:http://linkedlifedata.com/resource/pubmed/id/11596292

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2001-10-12
pubmed:abstractText
S-( -- )-Ligustiphenol is a new sesquiterpene with anti-inflammatory and immunosuppressive activities. In order to study its pharmacological activities, the total synthesis of its racemat was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m - cresol, protection of phenolic hydroxyl, Grignard reaction, Aldol condensation, etc. The target compound was characterized by comparing its 1(H)-NMR, MS and IR spectra with natural ( -- )-ligustiphenol. In order to study the structure-activity relationships of ligustiphenol, it five analogues were designed and synthesized. The pharmacological screening of these analogues has been performed.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0513-4870
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[Studies on the synthesis of dl-ligustiphenol and its analogues].
pubmed:affiliation
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
pubmed:publicationType
Journal Article, English Abstract