Source:http://linkedlifedata.com/resource/pubmed/id/11596286
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2001-10-12
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pubmed:abstractText |
The metabolites of dl-3-n-butylphthalide(NBP), a novel drug with promising protective action against cerebral ischemia, was studied in rats. Two main in vitro metabolites of NBP, M I and M II, were isolated and purified from rat liver microsome incubating system by using HPLC. The structure elucidation was mainly accomplished by spectral studies(UV, 1H-NMR, MS). Within 24 h following i.g. 3H-NBP, the total radioactivity excreted in urine and feces was 73.7% of the dose. Comparing with previous study, within 72 h following i.g. NBP, the total prototype drug excreted in urine and feces was 2.53% of the dose. This result excludes the possibility that NBP accumulates in vivo. The urine and brain homogenate of the rats(i.g. 3H-NBP) were analyzed by TLC. M I and M II were found in urine and M I was found in brain only. Furthermore, the ratio of radioactive M I to proptype drug was 1:1 in rat brain within 1 h following i.g. 3H-NBP. So, M I and M II were supposed to be the two main in vivo metabolites of NBP and M I might be an active metabolite.
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pubmed:language |
chi
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0513-4870
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
641-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11596286-Animals,
pubmed-meshheading:11596286-Benzofurans,
pubmed-meshheading:11596286-Brain,
pubmed-meshheading:11596286-Feces,
pubmed-meshheading:11596286-Male,
pubmed-meshheading:11596286-Neuroprotective Agents,
pubmed-meshheading:11596286-Rats,
pubmed-meshheading:11596286-Rats, Wistar
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pubmed:year |
1997
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pubmed:articleTitle |
[A study on the metabolites of dl-3-n-butyphthalide in rats].
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pubmed:affiliation |
Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050.
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
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