Linked Life Data

11595592

Source:http://linkedlifedata.com/resource/pubmed/id/11595592

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pubmed-article:11595592pubmed:abstractTextThe genomes of human Kaposi's sarcoma-associated herpesvirus (KSHV) display several levels of DNA sequence heterogeneity and subgrouping that show distinctive clustering patterns in related human populations. The four major subtype patterns for the hypervariable ORF-K1 protein correlate closely with the principal diasporas resulting from the migration of modern humans out of East Africa and suggest that KSHV is an ancient human virus that is transmitted primarily in a familial fashion with consequent very low recombination rates. However, chimeric genomes have also been detected, especially with regard to the presence of P versus M alleles of the ORF-K15 gene.lld:pubmed
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pubmed-article:11595592pubmed:articleTitleGenotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism.lld:pubmed
pubmed-article:11595592pubmed:affiliationMolecular Virology Laboratories, Department of Oncology, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB 3M09, Baltimore, MD 21205, USA.lld:pubmed
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