|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009085,
umls-concept:C0012854,
umls-concept:C0017431,
umls-concept:C0036220,
umls-concept:C0205314,
umls-concept:C0205419,
umls-concept:C0206558,
umls-concept:C0333678,
umls-concept:C0376526,
umls-concept:C0439064,
umls-concept:C0449774,
umls-concept:C0679622,
umls-concept:C0936012,
umls-concept:C1708726
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2001-10-11
|
|
pubmed:abstractText |
The genomes of human Kaposi's sarcoma-associated herpesvirus (KSHV) display several levels of DNA sequence heterogeneity and subgrouping that show distinctive clustering patterns in related human populations. The four major subtype patterns for the hypervariable ORF-K1 protein correlate closely with the principal diasporas resulting from the migration of modern humans out of East Africa and suggest that KSHV is an ancient human virus that is transmitted primarily in a familial fashion with consequent very low recombination rates. However, chimeric genomes have also been detected, especially with regard to the presence of P versus M alleles of the ORF-K15 gene.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1386-6532
|
|
pubmed:author |
pubmed-author:AlagiozoglouLeeL,
pubmed-author:BoshoffChrisC,
pubmed-author:BotoWilliamW,
pubmed-author:CiufoDolores MDM,
pubmed-author:HaywardGary SGS,
pubmed-author:KalumbujaHenryH,
pubmed-author:KangGyeong HGH,
pubmed-author:MelbyeMadsM,
pubmed-author:OrensteinJanJ,
pubmed-author:RadyPeterP,
pubmed-author:RomanoNinoN,
pubmed-author:TyringStephenS,
pubmed-author:ViscidiRaphaelR,
pubmed-author:ZongJianchaoJ
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
119-48
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11595592-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:11595592-Africa, Northern,
pubmed-meshheading:11595592-Alleles,
pubmed-meshheading:11595592-Amino Acid Sequence,
pubmed-meshheading:11595592-Europe,
pubmed-meshheading:11595592-Genome, Viral,
pubmed-meshheading:11595592-Genotype,
pubmed-meshheading:11595592-Herpesvirus 8, Human,
pubmed-meshheading:11595592-Humans,
pubmed-meshheading:11595592-Korea,
pubmed-meshheading:11595592-Membrane Proteins,
pubmed-meshheading:11595592-Middle East,
pubmed-meshheading:11595592-Molecular Sequence Data,
pubmed-meshheading:11595592-North America,
pubmed-meshheading:11595592-Open Reading Frames,
pubmed-meshheading:11595592-Phylogeny,
pubmed-meshheading:11595592-Recombination, Genetic,
pubmed-meshheading:11595592-Sarcoma, Kaposi,
pubmed-meshheading:11595592-Sequence Alignment,
pubmed-meshheading:11595592-Viral Envelope Proteins
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism.
|
|
pubmed:affiliation |
Molecular Virology Laboratories, Department of Oncology, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB 3M09, Baltimore, MD 21205, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|
