| pubmed-article:11595287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11595287 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11595287 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:11595287 | lifeskim:mentions | umls-concept:C0240816 | lld:lifeskim |
| pubmed-article:11595287 | lifeskim:mentions | umls-concept:C2754978 | lld:lifeskim |
| pubmed-article:11595287 | lifeskim:mentions | umls-concept:C0020852 | lld:lifeskim |
| pubmed-article:11595287 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:11595287 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:11595287 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:11595287 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:11595287 | pubmed:dateCreated | 2001-10-11 | lld:pubmed |
| pubmed-article:11595287 | pubmed:abstractText | Although HIV-specific cellular immune responses are found in a number of HIV highly-exposed, persistently seronegative (HEPS) cohorts, late seroconversion can occur despite pre-existing cytotoxic T lymphocytes (CTL), suggesting that a protective HIV vaccine may need to induce a broader range of HIV-specific immune responses. Low levels of HIV-specific IgA have been found in the genital tract and plasma of the majority of Nairobi HEPS sex workers and appeared to be independent of HIV-specific cellular responses. IgA purified from genital tract, saliva and plasma of most HEPS sex workers were able to neutralize infection of PBMC by a primary (NSI) clade B HIV isolate, as well as viral isolates from clades A and D, which predominate in Kenya. In addition, these IgA were able to inhibit transcytosis of infective HIV virions across a transwell model of the human mucosal epithelium in an HIV-specific manner. Preliminary work in other HEPS cohorts has suggested the recognition of different gp41 epitopes in HEPS and HIV-infected subjects. Although present at low levels, these IgA demonstrated cross-clade neutralizing activity and were able to inhibit HIV mucosal transcytosis, suggesting an important functional role in protection against HIV infection. | lld:pubmed |
| pubmed-article:11595287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11595287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11595287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11595287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11595287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11595287 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11595287 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:Kan?HH | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:ClericiMM | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:BrolidenKK | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:HinkulaJJ | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:PlummerFF | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:BwayoJ JJJ | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:DevitoCC | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:KimaniJJ | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:KiamaPP | lld:pubmed |
| pubmed-article:11595287 | pubmed:author | pubmed-author:TrabbatoniDD | lld:pubmed |
| pubmed-article:11595287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11595287 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11595287 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:11595287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11595287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11595287 | pubmed:pagination | 29-36 | lld:pubmed |
| pubmed-article:11595287 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11595287 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11595287 | pubmed:articleTitle | Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers. | lld:pubmed |
| pubmed-article:11595287 | pubmed:affiliation | Department of Clinical Virology, F68, Karolinska Institute, Huddinge University Hospital, S-141 86, Stockholm, Sweden. kristina.broliden@viruslab.hs.sll.se | lld:pubmed |
| pubmed-article:11595287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11595287 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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