Source:http://linkedlifedata.com/resource/pubmed/id/11595287
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2001-10-11
|
| pubmed:abstractText |
Although HIV-specific cellular immune responses are found in a number of HIV highly-exposed, persistently seronegative (HEPS) cohorts, late seroconversion can occur despite pre-existing cytotoxic T lymphocytes (CTL), suggesting that a protective HIV vaccine may need to induce a broader range of HIV-specific immune responses. Low levels of HIV-specific IgA have been found in the genital tract and plasma of the majority of Nairobi HEPS sex workers and appeared to be independent of HIV-specific cellular responses. IgA purified from genital tract, saliva and plasma of most HEPS sex workers were able to neutralize infection of PBMC by a primary (NSI) clade B HIV isolate, as well as viral isolates from clades A and D, which predominate in Kenya. In addition, these IgA were able to inhibit transcytosis of infective HIV virions across a transwell model of the human mucosal epithelium in an HIV-specific manner. Preliminary work in other HEPS cohorts has suggested the recognition of different gp41 epitopes in HEPS and HIV-infected subjects. Although present at low levels, these IgA demonstrated cross-clade neutralizing activity and were able to inhibit HIV mucosal transcytosis, suggesting an important functional role in protection against HIV infection.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0165-2478
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
79
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
29-36
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:11595287-Antibody Specificity,
pubmed-meshheading:11595287-Cohort Studies,
pubmed-meshheading:11595287-Epitopes,
pubmed-meshheading:11595287-Female,
pubmed-meshheading:11595287-Genitalia, Female,
pubmed-meshheading:11595287-HIV Antibodies,
pubmed-meshheading:11595287-HIV Antigens,
pubmed-meshheading:11595287-HIV Infections,
pubmed-meshheading:11595287-HIV Seronegativity,
pubmed-meshheading:11595287-HIV-1,
pubmed-meshheading:11595287-Humans,
pubmed-meshheading:11595287-Immunity, Innate,
pubmed-meshheading:11595287-Immunity, Mucosal,
pubmed-meshheading:11595287-Immunoglobulin A,
pubmed-meshheading:11595287-Immunoglobulin G,
pubmed-meshheading:11595287-Kenya,
pubmed-meshheading:11595287-Neutralization Tests,
pubmed-meshheading:11595287-Prostitution,
pubmed-meshheading:11595287-T-Lymphocytes, Helper-Inducer
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers.
|
| pubmed:affiliation |
Department of Clinical Virology, F68, Karolinska Institute, Huddinge University Hospital, S-141 86, Stockholm, Sweden. kristina.broliden@viruslab.hs.sll.se
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|