Linked Life Data

11595262

Source:http://linkedlifedata.com/resource/pubmed/id/11595262

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-10-11
pubmed:abstractText
Patients with semantic impairments sometimes demonstrate category-specific deficits suggesting that the anatomical substrates of semantic memory may reflect categorical organisation, however, neuroimaging studies have failed to provide consistent data in support of a category-based account. We conducted three functional neuroimaging experiments to investigate the neural correlates of semantic processing, two with positron emission tomography (PET) and a third with functional magnetic resonance imaging (fMRI). The first experiment used a lexical decision task to search for brain regions selectively activated by concepts from four different categories--animals, fruit, tools, and vehicles. The second experiment used a semantic categorisation task to increase the demands on the semantic system and to look for evidence of consistent activations for the domains of natural kinds or man-made items. The final experiment was a replication of the semantic categorisation task using fMRI to increase the spatial resolution and statistical sensitivity of the experiment. The results of these experiments reliably identified a distributed neural system common to both natural kinds and artifacts but failed to find robust evidence of functional segregation by domain or categories. Category effects were neither reliable nor consistently present across experiments although some were consistent with previous studies. We discuss the implications of these findings, arguing that they are most consistent with a semantic system undifferentiated by category at the neural level.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0028-3932
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
54-75
pubmed:dateRevised
2010-5-20
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Is there an anatomical basis for category-specificity? Semantic memory studies in PET and fMRI.
pubmed:affiliation
Centre for Functional Magnetic Resonance Imaging of the Brain and the Department of Experimental Psychology, Oxford University, John Radcliffe Hospital, Headley Way, Oxford, UK. devlin@fmrib.ox.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't