| pubmed-article:11595069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11595069 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:11595069 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:11595069 | lifeskim:mentions | umls-concept:C0003448 | lld:lifeskim |
| pubmed-article:11595069 | lifeskim:mentions | umls-concept:C0764347 | lld:lifeskim |
| pubmed-article:11595069 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:11595069 | lifeskim:mentions | umls-concept:C0235378 | lld:lifeskim |
| pubmed-article:11595069 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11595069 | lifeskim:mentions | umls-concept:C0456148 | lld:lifeskim |
| pubmed-article:11595069 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11595069 | pubmed:dateCreated | 2001-10-11 | lld:pubmed |
| pubmed-article:11595069 | pubmed:abstractText | Pathogenesis and genetic factors influencing predisposition to antituberculosis drug (ATD)-induced hepatotoxicity are not clear. Polymorphism at the genetic locus of a drug and xenobiotic compound metabolizing enzyme, N-acetyltransferase type 2 (NAT2), is reported to be associated with the excess generation of toxic reactive metabolites. Polymorphisms at the glutathione S-transferase (GST) loci (GSTM1 and GSTT1) are involved in the detoxification of these toxic metabolites in the human body to a lesser extent. We have examined whether polymorphisms at these loci are associated with the risk of ATD-induced hepatotoxicity. | lld:pubmed |
| pubmed-article:11595069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11595069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11595069 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11595069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11595069 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11595069 | pubmed:issn | 0815-9319 | lld:pubmed |
| pubmed-article:11595069 | pubmed:author | pubmed-author:ChakrabortyMM | lld:pubmed |
| pubmed-article:11595069 | pubmed:author | pubmed-author:RoyBB | lld:pubmed |
| pubmed-article:11595069 | pubmed:author | pubmed-author:KunduSS | lld:pubmed |
| pubmed-article:11595069 | pubmed:author | pubmed-author:MajumderP PPP | lld:pubmed |
| pubmed-article:11595069 | pubmed:author | pubmed-author:ChowdhuryAA | lld:pubmed |
| pubmed-article:11595069 | pubmed:author | pubmed-author:DeiRR | lld:pubmed |
| pubmed-article:11595069 | pubmed:author | pubmed-author:SantraAA | lld:pubmed |
| pubmed-article:11595069 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11595069 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:11595069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11595069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11595069 | pubmed:pagination | 1033-7 | lld:pubmed |
| pubmed-article:11595069 | pubmed:dateRevised | 2010-9-8 | lld:pubmed |
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| pubmed-article:11595069 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11595069 | pubmed:articleTitle | Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation. | lld:pubmed |
| pubmed-article:11595069 | pubmed:affiliation | Anthropology and Human Genetics Unit, Indian Statistical Institute, Calcutta, India. broyisi@hotmail.com | lld:pubmed |
| pubmed-article:11595069 | pubmed:publicationType | Journal Article | lld:pubmed |
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