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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-10-11
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pubmed:abstractText |
Pathogenesis and genetic factors influencing predisposition to antituberculosis drug (ATD)-induced hepatotoxicity are not clear. Polymorphism at the genetic locus of a drug and xenobiotic compound metabolizing enzyme, N-acetyltransferase type 2 (NAT2), is reported to be associated with the excess generation of toxic reactive metabolites. Polymorphisms at the glutathione S-transferase (GST) loci (GSTM1 and GSTT1) are involved in the detoxification of these toxic metabolites in the human body to a lesser extent. We have examined whether polymorphisms at these loci are associated with the risk of ATD-induced hepatotoxicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0815-9319
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1033-7
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pubmed:dateRevised |
2010-9-8
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pubmed:meshHeading |
pubmed-meshheading:11595069-Adolescent,
pubmed-meshheading:11595069-Adult,
pubmed-meshheading:11595069-Aged,
pubmed-meshheading:11595069-Antitubercular Agents,
pubmed-meshheading:11595069-Arylamine N-Acetyltransferase,
pubmed-meshheading:11595069-Case-Control Studies,
pubmed-meshheading:11595069-DNA Mutational Analysis,
pubmed-meshheading:11595069-Drug Therapy, Combination,
pubmed-meshheading:11595069-Drug-Induced Liver Injury,
pubmed-meshheading:11595069-Female,
pubmed-meshheading:11595069-Glutathione Transferase,
pubmed-meshheading:11595069-Humans,
pubmed-meshheading:11595069-Liver Function Tests,
pubmed-meshheading:11595069-Male,
pubmed-meshheading:11595069-Metabolic Detoxication, Drug,
pubmed-meshheading:11595069-Middle Aged,
pubmed-meshheading:11595069-Mutation,
pubmed-meshheading:11595069-Polymerase Chain Reaction,
pubmed-meshheading:11595069-Polymorphism, Genetic,
pubmed-meshheading:11595069-Risk Factors,
pubmed-meshheading:11595069-Tuberculosis, Pulmonary
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pubmed:year |
2001
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pubmed:articleTitle |
Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation.
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pubmed:affiliation |
Anthropology and Human Genetics Unit, Indian Statistical Institute, Calcutta, India. broyisi@hotmail.com
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pubmed:publicationType |
Journal Article
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