Linked Life Data

11594458

Source:http://linkedlifedata.com/resource/pubmed/id/11594458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-10-11
pubmed:abstractText
A number of mouse models have been utilized to study the pathophysiology of immune complex (IC) disease, and the hallmark IC disease systemic lupus erythematosus (SLE). Many of these studies have provided exciting new insights into IC-mediated inflammation and autoimmunity. However, numerous differences exist between mice and humans that suggest that mouse studies are not always applicable to human disease. These differences can be found in the biological systems that interact with circulating IC, in the specifics of disease presentation, and in the general physiology of the two species. Furthermore, although the mechanisms of SLE-like autoimmune disease in the mouse are being defined through analyses of the murine models of SLE, it remains to be proven that these mechanisms are relevant to human SLE. Thus, generalizing the results of the mouse studies to human SLE and other human IC diseases must be done with caution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0257-277X
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-24
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Of mice and men: the relevance of the mouse to the study of human SLE.
pubmed:affiliation
The Department of Internal Medicine, The Heart Lung Research Institute, The Ohio State University, Columbus, USA. birmingham-1@medctr.osu.edu
pubmed:publicationType
Journal Article, Review