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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2001-10-9
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pubmed:abstractText |
A series of compounds was designed and prepared as inhibitors of interleukin-1beta converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable interactions between the diphenyl ether rings and the prime side hydrophobic region. An X-ray crystal structure of a representative member of the diphenyl ether sulfonamide series bound to the active site of caspase-1 was obtained.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AllenH JHJ,
pubmed-author:BradyK DKD,
pubmed-author:ConnollyM KMK,
pubmed-author:HumbletCC,
pubmed-author:LunneyE AEA,
pubmed-author:PlummerM SMS,
pubmed-author:RubinJ RJR,
pubmed-author:SawyerT KTK,
pubmed-author:ShahripourA BAB,
pubmed-author:StankovicC JCJ,
pubmed-author:TalanianR VRV,
pubmed-author:WalkerN PNP,
pubmed-author:WongW WWW
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2779-82
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pubmed:meshHeading |
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pubmed:year |
2001
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pubmed:articleTitle |
Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide.
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pubmed:affiliation |
Department of Chemistry, Pfizer Global Research & Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. shahipour@pfizer.com
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pubmed:publicationType |
Journal Article
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