Source:http://linkedlifedata.com/resource/pubmed/id/11591508
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
20
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pubmed:dateCreated |
2001-10-9
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pubmed:abstractText |
A series of N(1)- and N(2)-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N(1)- and N(2)-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2715-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11591508-Animals,
pubmed-meshheading:11591508-Hippocampus,
pubmed-meshheading:11591508-Mice,
pubmed-meshheading:11591508-Monoamine Oxidase Inhibitors,
pubmed-meshheading:11591508-Neuroprotective Agents,
pubmed-meshheading:11591508-Norepinephrine,
pubmed-meshheading:11591508-Phenelzine
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pubmed:year |
2001
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pubmed:articleTitle |
Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.
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pubmed:affiliation |
CV Technologies Inc., Edmonton Research Park, 9411-20 Ave., Edmonton, T6N 1E5, Alberta, Canada. linglei@cvtechnologies.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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