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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-10-9
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pubmed:abstractText |
Histamine is important in mediating peripheral sensory information such as inflammation, allergic hypersensitivity, and itch. In the present study, using video-enhanced microscopy, we investigated the effect of histamine on axonal transport in cultured dorsal root ganglion (DRG) neurons of the mouse. Application of histamine (100 microM) reversibly reduced the number of particles transported within neurites in both anterograde and retrograde directions. The histamine H(1)-receptor agonist 2-thiazolylethylamine (100 microM) and the H(3)-receptor agonist R-alpha-methylhistamine (100 microM) also reduced anterograde and retrograde axonal transport, whereas the histamine H(2)-receptor agonist dimaprit (100-1000 microM) had no effect. The effect of histamine was partially blocked by pretreatment with H(1)-receptor antagonist pyrilamine (1 microM) or the H(3)-receptor antagonist thioperamide (1 microM). Pretreatment with a combination of pyrilamine (1 microM) and thioperamide (1 microM) completely blocked the response to histamine. The H(2)-receptor antagonist cimetidine (1 microM) was ineffective. These results suggest that histamine inhibits axonal transport of cultured mouse DRG neurons via the activation of H(1)- and H(3)-receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H1 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H2 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H3
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0168-0102
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11591447-Animals,
pubmed-meshheading:11591447-Axonal Transport,
pubmed-meshheading:11591447-Axons,
pubmed-meshheading:11591447-Cells, Cultured,
pubmed-meshheading:11591447-Drug Interactions,
pubmed-meshheading:11591447-Ganglia, Spinal,
pubmed-meshheading:11591447-Histamine,
pubmed-meshheading:11591447-Histamine Agonists,
pubmed-meshheading:11591447-Histamine H1 Antagonists,
pubmed-meshheading:11591447-Histamine H2 Antagonists,
pubmed-meshheading:11591447-Male,
pubmed-meshheading:11591447-Mice,
pubmed-meshheading:11591447-Mice, Inbred C57BL,
pubmed-meshheading:11591447-Microscopy, Video,
pubmed-meshheading:11591447-Neurons, Afferent,
pubmed-meshheading:11591447-Receptors, Histamine,
pubmed-meshheading:11591447-Receptors, Histamine H1,
pubmed-meshheading:11591447-Receptors, Histamine H2,
pubmed-meshheading:11591447-Receptors, Histamine H3
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pubmed:year |
2001
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pubmed:articleTitle |
Inhibitory effect of histamine on axonal transport in cultured mouse dorsal root ganglion neurons.
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pubmed:affiliation |
Department of Ophthalmology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 228-8555, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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