Linked Life Data

11591130

Source:http://linkedlifedata.com/resource/pubmed/id/11591130

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pubmed-article:11591130pubmed:abstractTextMetabotropic glutamate receptor 5 (mGluR5) can modulate synaptic transmission by increasing intracellular Ca2+ and it plays a role in several forms of synaptic plasticity. We have constructed a fusion of human mGluR5 and green fluorescent protein (mGluR5-GFP). Expression of mGluR5-GFP in clonal cell lines yielded a functional fluorescent receptor with pharmacological profiles similar to wild-type mGluR5. mGluR5-GFP coimmunoprecipitated with Homer-1c, indicating that addition of GFP to the C-terminal did not prevent Homer binding. Coexpression of wild-type mGluR5 or mGluR5-GFP with Homer 1c, but not Homer-1a, resulted in reduced receptor surface localization and the formation of intracellular clusters. Neither Homer-1a nor Homer-1c had any effect on mGluR1 or mGluR1-GFP distribution. mGluR5-GFP expressed alone or in combination with Homer-1a formed dimers in HEK cells. Coexpression with Homer-1c, however, prevented mGluR5-GFP dimerization. Neither Homer altered the agonist profiles of mGluR5 or mGluR5-GFP. These data indicate that the functional expression of mGluR5 is regulated by Homer-1c and demonstrate that mGluR5-GFP provides a useful tool to study the molecular pharmacology and cell biology of mGluRs in real-time.lld:pubmed
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pubmed-article:11591130pubmed:authorpubmed-author:SugiyamaHHlld:pubmed
pubmed-article:11591130pubmed:authorpubmed-author:CoutinhoVVlld:pubmed
pubmed-article:11591130pubmed:authorpubmed-author:HenleyJ MJMlld:pubmed
pubmed-article:11591130pubmed:authorpubmed-author:TonesM AMAlld:pubmed
pubmed-article:11591130pubmed:authorpubmed-author:KavanaghIIlld:pubmed
pubmed-article:11591130pubmed:copyrightInfoCopyright 2001 Academic Press.lld:pubmed
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pubmed-article:11591130pubmed:volume18lld:pubmed
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pubmed-article:11591130pubmed:pagination296-306lld:pubmed
pubmed-article:11591130pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11591130pubmed:articleTitleCharacterization of a metabotropic glutamate receptor type 5-green fluorescent protein chimera (mGluR5-GFP): pharmacology, surface expression, and differential effects of Homer-1a and Homer-1c.lld:pubmed
pubmed-article:11591130pubmed:affiliationMRC Centre for Synaptic Plasticity, University Walk, Bristol, BS8 1TD, United Kingdom.lld:pubmed
pubmed-article:11591130pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11591130pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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