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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1514873,
umls-concept:C1516349,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
11
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pubmed:dateCreated |
2001-10-30
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pubmed:abstractText |
In vivo models have shown that tissue-restricted antigen may be captured by bone marrow-derived cells and cross-presented for the tolerization of CD8+ T cells. Although these studies have shown peripheral tolerization of CD8+ T cells, the mechanism of antigen transfer and the nature of the antigen-presenting cell (APC) remain undefined. We report here the establishment of an in vitro system for the study of cross-tolerance and show that dendritic cells (DCs) phagocytose apoptotic cells and tolerize antigen-specific CD8+ T cells when cognate CD4+ T helper cells are absent. Using this system, we directly tested the "two-signal" hypothesis for the regulation of priming versus tolerance. We found that the same CD83+ myeloid-derived DCs were required for both cross-priming and cross-tolerance. These data suggested that the current model for peripheral T cell tolerance, "signal 1 in the absence of signal 2", requires refinement: the critical checkpoint is not DC maturation, but instead the presence of a third signal, which is active at the DC-CD4+ T cell interface.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/CD83 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1010-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11590405-Antigen Presentation,
pubmed-meshheading:11590405-Antigens, CD,
pubmed-meshheading:11590405-Antigens, CD28,
pubmed-meshheading:11590405-Antigens, CD40,
pubmed-meshheading:11590405-Antigens, Differentiation,
pubmed-meshheading:11590405-Antigens, Viral,
pubmed-meshheading:11590405-Apoptosis,
pubmed-meshheading:11590405-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11590405-CD40 Ligand,
pubmed-meshheading:11590405-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11590405-CTLA-4 Antigen,
pubmed-meshheading:11590405-Cell Communication,
pubmed-meshheading:11590405-Cell Differentiation,
pubmed-meshheading:11590405-Cells, Cultured,
pubmed-meshheading:11590405-Coculture Techniques,
pubmed-meshheading:11590405-Cross-Over Studies,
pubmed-meshheading:11590405-Culture Media, Conditioned,
pubmed-meshheading:11590405-Dendritic Cells,
pubmed-meshheading:11590405-HLA-DR Antigens,
pubmed-meshheading:11590405-Humans,
pubmed-meshheading:11590405-Immune Tolerance,
pubmed-meshheading:11590405-Immunoconjugates,
pubmed-meshheading:11590405-Immunoglobulins,
pubmed-meshheading:11590405-Interleukin-1,
pubmed-meshheading:11590405-Interleukin-12,
pubmed-meshheading:11590405-Lymphocyte Activation,
pubmed-meshheading:11590405-Membrane Glycoproteins,
pubmed-meshheading:11590405-Models, Immunological,
pubmed-meshheading:11590405-Orthomyxoviridae,
pubmed-meshheading:11590405-Phagocytosis,
pubmed-meshheading:11590405-Signal Transduction,
pubmed-meshheading:11590405-Tumor Necrosis Factor-alpha
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pubmed:year |
2001
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pubmed:articleTitle |
Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells.
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pubmed:affiliation |
Laboratory of Neuro-Oncology, The Rockefeller University, 1230 York Avenue, Box 26, New York, NY 10021, USA. albertm@rockvax.rockefeller.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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