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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-10-5
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pubmed:abstractText |
Nitric oxide (NO) reduces endothelin-1 (ET-1) production and blunts ET-1 dependent vasoconstriction. The direct effects of smooth muscle ET(A) receptor stimulation on NO-mediated relaxation are unknown. We hypothesized that endothelium-derived ET-1 regulates vascular tone by reducing smooth muscle sensitivity to NO, possibly through activation of protein kinase C (PKC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Endothelin A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Endothelin B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Endothelin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2351-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11588325-Animals,
pubmed-meshheading:11588325-Antihypertensive Agents,
pubmed-meshheading:11588325-Dose-Response Relationship, Drug,
pubmed-meshheading:11588325-Endothelin-1,
pubmed-meshheading:11588325-Endothelium, Vascular,
pubmed-meshheading:11588325-Enzyme Activators,
pubmed-meshheading:11588325-Enzyme Inhibitors,
pubmed-meshheading:11588325-Female,
pubmed-meshheading:11588325-Free Radical Scavengers,
pubmed-meshheading:11588325-Indomethacin,
pubmed-meshheading:11588325-Male,
pubmed-meshheading:11588325-Middle Cerebral Artery,
pubmed-meshheading:11588325-Nitric Oxide,
pubmed-meshheading:11588325-Protein Kinase C,
pubmed-meshheading:11588325-Rabbits,
pubmed-meshheading:11588325-Receptor, Endothelin A,
pubmed-meshheading:11588325-Receptor, Endothelin B,
pubmed-meshheading:11588325-Receptors, Endothelin,
pubmed-meshheading:11588325-Signal Transduction,
pubmed-meshheading:11588325-Vasoconstriction,
pubmed-meshheading:11588325-Vasodilation,
pubmed-meshheading:11588325-Vasodilator Agents,
pubmed-meshheading:11588325-Vasomotor System
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pubmed:year |
2001
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pubmed:articleTitle |
Endothelium-derived endothelin-1 reduces cerebral artery sensitivity to nitric oxide by a protein kinase C-independent pathway.
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pubmed:affiliation |
Institut de cardiologie de Montréal, Montréal, Québec, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro
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