| pubmed-article:11588176 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C0039065 | lld:lifeskim |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C0034850 | lld:lifeskim |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C1749557 | lld:lifeskim |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11588176 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11588176 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:11588176 | pubmed:dateCreated | 2001-10-5 | lld:pubmed |
| pubmed-article:11588176 | pubmed:abstractText | Heterotetrameric adaptor complexes vesiculate donor membranes. One of the adaptor protein complexes, AP-3, is present in two forms; one form is expressed in all tissues of the body, whereas the other is restricted to brain. Mice lacking both the ubiquitous and neuronal forms of AP-3 exhibit neurological disorders that are not observed in mice that are mutant only in the ubiquitous form. To begin to understand the role of neuronal AP-3 in neurological disease, we investigated its function in in vitro assays as well as its localization in neural tissue. In the presence of GTPgammaS both ubiquitous and neuronal forms of AP-3 can bind to purified synaptic vesicles. However, only the neuronal form of AP-3 can produce synaptic vesicles from endosomes in vitro. We also identified that the expression of neuronal AP-3 is limited to varicosities of neuronal-like processes and is expressed in most axons of the brain. Although the AP-2/clathrin pathway is the major route of vesicle production and the relatively minor neuronal AP-3 pathway is not necessary for viability, the absence of the latter could lead to the neurological abnormalities seen in mice lacking the expression of AP-3 in brain. In this study we have identified the first brain-specific function for a neuronal adaptor complex. | lld:pubmed |
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| pubmed-article:11588176 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11588176 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11588176 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11588176 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11588176 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11588176 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:11588176 | pubmed:author | pubmed-author:KellyR BRB | lld:pubmed |
| pubmed-article:11588176 | pubmed:author | pubmed-author:SaitoTT | lld:pubmed |
| pubmed-article:11588176 | pubmed:author | pubmed-author:OhnoHH | lld:pubmed |
| pubmed-article:11588176 | pubmed:author | pubmed-author:FaundezVV | lld:pubmed |
| pubmed-article:11588176 | pubmed:author | pubmed-author:BlumsteinJJ | lld:pubmed |
| pubmed-article:11588176 | pubmed:author | pubmed-author:NakatsuFF | lld:pubmed |
| pubmed-article:11588176 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11588176 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11588176 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11588176 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11588176 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11588176 | pubmed:pagination | 8034-42 | lld:pubmed |
| pubmed-article:11588176 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11588176 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11588176 | pubmed:articleTitle | The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes. | lld:pubmed |
| pubmed-article:11588176 | pubmed:affiliation | Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0448, USA. | lld:pubmed |
| pubmed-article:11588176 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11588176 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11588176 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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