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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-10-5
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pubmed:abstractText |
Interleukin-1beta is a multifunctional cytokine produced by activated monocytes and macrophages that requires caspase-1 (IL-1 converting enzyme/ICE) to process the 31kDa inactive precursor protein to the biologically active 17kDa peptide. This activation event involves ICE cleavage at Asp27 (site 1) and Asp116 (site 2). To address the sequential processing at ICE cut sites we combined in vitro analysis and molecular modeling to investigate the sequence of molecular events.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0724-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1083-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11587477-Amino Acid Sequence,
pubmed-meshheading:11587477-Caspase 1,
pubmed-meshheading:11587477-Computer Simulation,
pubmed-meshheading:11587477-Crystallization,
pubmed-meshheading:11587477-Humans,
pubmed-meshheading:11587477-Interleukin-1,
pubmed-meshheading:11587477-Methionine,
pubmed-meshheading:11587477-Models, Molecular,
pubmed-meshheading:11587477-Monocytes,
pubmed-meshheading:11587477-Precipitin Tests,
pubmed-meshheading:11587477-Protein Folding,
pubmed-meshheading:11587477-Protein Precursors,
pubmed-meshheading:11587477-Sulfur Radioisotopes
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pubmed:year |
2001
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pubmed:articleTitle |
Sequential processing of human ProIL-1beta by caspase-1 and subsequent folding determined by a combined in vitro and in silico approach.
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pubmed:affiliation |
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus 43210, USA. swaan.1@osu.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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