Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-10-5
pubmed:abstractText
FISH identified a cryptic t(5;14)(q35;q32) in T acute lymphoblastic leukemia (ALL), whereas it was not observed in B ALL samples. This translocation is present in five out of 23 (22%) children and adolescents with T ALL tested. RanBP17, a gene coding for a member of the importin beta protein family, and Hox11Like2, an orphan homeobox gene were mapped close to the chromosome 5 breakpoints and CTIP2, which is highly expressed during normal T cell differentiation, was localized in the vicinity of the chromosome 14 breakpoints. The Hox11L2 gene was found to be transcriptionally activated as a result of the translocation, probably under the influence of CTIP2 transcriptional regulation elements. These data establish the t(5;14)(q35;q32) as a major abnormality, and Hox11 family member activation as an important pathway in T ALL leukemogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1495-504
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11587205-Adolescent, pubmed-meshheading:11587205-Adult, pubmed-meshheading:11587205-Amino Acid Sequence, pubmed-meshheading:11587205-Case-Control Studies, pubmed-meshheading:11587205-Cell Transformation, Neoplastic, pubmed-meshheading:11587205-Child, pubmed-meshheading:11587205-Child, Preschool, pubmed-meshheading:11587205-Chromosome Breakage, pubmed-meshheading:11587205-Chromosomes, Human, Pair 14, pubmed-meshheading:11587205-Chromosomes, Human, Pair 5, pubmed-meshheading:11587205-Cytogenetic Analysis, pubmed-meshheading:11587205-Female, pubmed-meshheading:11587205-Homeodomain Proteins, pubmed-meshheading:11587205-Humans, pubmed-meshheading:11587205-Leukemia-Lymphoma, Adult T-Cell, pubmed-meshheading:11587205-Male, pubmed-meshheading:11587205-Molecular Sequence Data, pubmed-meshheading:11587205-Oncogene Proteins, pubmed-meshheading:11587205-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:11587205-Proto-Oncogene Proteins, pubmed-meshheading:11587205-Sequence Alignment, pubmed-meshheading:11587205-Translocation, Genetic, pubmed-meshheading:11587205-ran GTP-Binding Protein
pubmed:year
2001
pubmed:articleTitle
A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.
pubmed:affiliation
U434 INSERM-CEPH and SD401 No. 434 CNRS, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't