Source:http://linkedlifedata.com/resource/pubmed/id/11579346
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2001-10-1
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pubmed:abstractText |
The Glu298Asp polymorphism of endothelial nitric oxide synthase (eNOS) gene has been associated with coronary artery disease (CAD) in some but not all studies. To determine the impact of the mutant Asp298 eNOS allele on the development of premature CAD, we examined the prevalence of this mutation in patients with early-onset CAD compared with those manifesting CAD later in life. If this mutation confers an increased risk of premature CAD, we hypothesized that the frequency of the homozygous mutation (Asp298Asp298) would be greater among the younger patient group.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1097-6744
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
586-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11579346-Age Factors,
pubmed-meshheading:11579346-Age of Onset,
pubmed-meshheading:11579346-Aged,
pubmed-meshheading:11579346-Coronary Disease,
pubmed-meshheading:11579346-Endothelium,
pubmed-meshheading:11579346-Gene Frequency,
pubmed-meshheading:11579346-Genotype,
pubmed-meshheading:11579346-Humans,
pubmed-meshheading:11579346-Middle Aged,
pubmed-meshheading:11579346-Nitric Oxide Synthase,
pubmed-meshheading:11579346-Polymorphism, Genetic
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pubmed:year |
2001
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pubmed:articleTitle |
Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease.
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pubmed:affiliation |
Department of Pathology, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada. plmban@qe2-hsc.ns.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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