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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2001-10-1
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pubmed:abstractText |
Germline mutations in mismatch repair genes predispose to hereditary nonpolyposis colorectal cancer (HNPCC). To address effective screening programs, the true incidence of the disease must be known. Previous clinical investigations reported estimates ranging between 0.5% and 13% of all the colorectal cancer (CRC) cases, whereas biomolecular studies in Finland found an incidence of 2% to 2.7% of mutation carriers for the disease. The aim of the present report is to establish the frequency of the disease in a high-incidence area for colon cancer.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:BenattiPP,
pubmed-author:BorghiFF,
pubmed-author:Di GregorioCC,
pubmed-author:ForoniMM,
pubmed-author:GenuardiMM,
pubmed-author:KristyJJ,
pubmed-author:LosiLL,
pubmed-author:MarraGG,
pubmed-author:MenigattiMM,
pubmed-author:PedroniMM,
pubmed-author:PeltomäkiPP,
pubmed-author:PercesepeAA,
pubmed-author:Ponz de LeonMM,
pubmed-author:RoncucciLL,
pubmed-author:RossiGG,
pubmed-author:SalaEE,
pubmed-author:VaccinaFF,
pubmed-author:VielAA
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3944-50
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11579115-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11579115-Adult,
pubmed-meshheading:11579115-Aged,
pubmed-meshheading:11579115-Aged, 80 and over,
pubmed-meshheading:11579115-Carrier Proteins,
pubmed-meshheading:11579115-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:11579115-DNA Mutational Analysis,
pubmed-meshheading:11579115-DNA-Binding Proteins,
pubmed-meshheading:11579115-Female,
pubmed-meshheading:11579115-Genetic Predisposition to Disease,
pubmed-meshheading:11579115-Genetic Testing,
pubmed-meshheading:11579115-Germ-Line Mutation,
pubmed-meshheading:11579115-Humans,
pubmed-meshheading:11579115-Immunohistochemistry,
pubmed-meshheading:11579115-Incidence,
pubmed-meshheading:11579115-Male,
pubmed-meshheading:11579115-Microsatellite Repeats,
pubmed-meshheading:11579115-Middle Aged,
pubmed-meshheading:11579115-MutS Homolog 2 Protein,
pubmed-meshheading:11579115-Neoplasm Proteins,
pubmed-meshheading:11579115-Nuclear Proteins,
pubmed-meshheading:11579115-Prospective Studies,
pubmed-meshheading:11579115-Proto-Oncogene Proteins,
pubmed-meshheading:11579115-Registries
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pubmed:year |
2001
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pubmed:articleTitle |
Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study.
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pubmed:affiliation |
Department of Internal Medicine, University of Modena, Modena, Italy. percesepe.antonio@unimo.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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